St Louis Cardinals vs Chicago Cubs Prediction, Preview and Odds - 08/15/2026

Game Time: 2:20 pm ET, Saturday, August 15, 2026

Venue:  Wrigley Field, Chicago, IL 

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Cardinals +149, Cubs -181; Over/Under:  9 runs

Bet365:  Moneyline odds:  Cardinals +150, Cubs -180; Over/Under:  9 runs

BetMGM:  Moneyline odds:  Cardinals +150, Cubs -180; Over/Under:  9 runs

St Louis Cardinals:  61-60 (3rd place, NL Central)

Chicago Cubs:  71-51 (2nd place, NL Central)

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St Louis Cardinals:  7-3 last 10

Chicago Cubs:  8-2 last 10

The Cardinals are entering this series off a win and won their 3-game series against the Philadelphia Phillies 2-1 in their last series. They enter this game with a 61-60 record overall and have a road record of 29-26. This is the 2nd game of a 3-game series with the Cubs on Saturday with the series opener still to be played on Friday. Their offense ranks 25th in the MLB with a .695 OPS. Matthew Liberatore is their starting pitcher on Friday while Michael McGreevy is making his start in this game on Saturday. He is 4-9 with a 3.64 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 3 ER, 1 HR, and 2 BB with 4 SO on 8 hits through 5.2 IP against the Colorado Rockies.

The Cubs are entering this series off a loss and won their 3-game series against the Washington Nationals 2-1 in their last series. They enter this game with a 71-51 record overall and have a home record of 35-24. This is the 2nd game of a 3-game series with the Cardinals on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 3rd in the MLB with a .757 OPS. Clay Holmes is their starting pitcher on Friday while Matthew Boyd is making his start in this game on Saturday. He is 8-1 with a 3.50 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 1 homer, and 3 walks with 3 strikeouts on 5 hits through 7 innings pitched against the Kansas City Royals.

The current betting odds have the Cubs listed as a favorite in this game according to Draftkings Sportsbook. The Cubs have looked great in their games this season with their 71-51 record overall which has them right near the top of the NL Central. They have looked great in their own ballpark too with their 35-24 home record this season. Meanwhile, the Cardinals have looked good in their games this season with their 61-60 record overall which has them right in the middle of the NL Central. They have been a good road team too with their 29-26 road record this year. The Cardinals are 7-3 in their last 10 games and they have been rolling lately, but they are still just right around .500 being really up and down all year. The Cubs have also been rolling lately, now 8-2 in their last 10 games, and they have consistently been one of the best teams in the league all season. The Cubs are going with Boyd in this one and he has looked great for them this year. He is 8-1 with a 3.50 ERA and the team has been having a ton of success with him lately. He is coming off another great start giving up 2 earned runs which has been a common theme for him and the team has won 2 games in a row now with him starting too. The Cardinals are going with McGreevy in this one and he hasn't looked bad this season. He is 4-9 with a 3.64 ERA and hasn't been giving up a ton of runs, but the team hasn't had a lot of success with him either. They have won 2 games in a row now with him starting, but that hasn't been a common theme with him this year and he did give up 3 earned runs in his last start, not looking as good lately. Look for the Cubs to take advantage of this pitching matchup at home as they also have one of the best offenses in MLB to lean on. The best way to place a bet here is on the Cubs to win this game. 

Cardinals Cubs Prediction:  Our MLB Pick for Saturday, August 15, 2026 (2:20 pm ET start time) is Cubs 4 Cardinals 3.

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St Louis Cardinals: 15-35 (-8.8 units) on the moneyline as a road underdog of +150 or more. 67-73 (-5.2 units) on the moneyline against division opponents. 145-164 (-9.4 units) on the moneyline vs. a team with a good bullpen whose WHIP is 1.350 or better. 26-16 UNDER as a road underdog of +100 or higher.

Chicago Cubs: 251-203 (+22.1 units) on the moneyline in all games. 134-92 (+14.1 units) on the moneyline in home games. 165-107 (+14.3 units) on the moneyline as a favorite of -110 or higher. 6-3 UNDER at home vs. an NL starting pitcher whose WHIP is 1.250 or better.

St Louis Cardinals:  M. Rajcic (SP) Sixty Day IL - Elbow. R. Urias (3B) Sixty Day IL - Elbow.

Chicago Cubs:  B. Brown (RP) Sixty Day IL - Neck. G. Hollowell (RP) Fifteen Day IL - Shoulder. P. Maton (RP) Fifteen Day IL - Knee. M. Shaw (RF) Ten Day IL - Hand. H. Milner (RP) Fifteen Day IL - Appendicitis. E. Cabrera (SP) Fifteen Day IL - Hamstring. D. Palencia (RP) Fifteen Day IL - Elbow. R. Martin (RP) Sixty Day IL - Elbow. P. Hodge (RP) Sixty Day IL - Elbow. C. Horton (SP) Sixty Day IL - Forearm. H. Harvey (RP) Sixty Day IL - Tricep. J. Steele (SP) Sixty Day IL - Elbow. T. Austin (1B) Sixty Day IL - Knee. S. Miller (RP) Sixty Day IL - Elbow.

“Sánchez and Wheeler, those are two playoff-caliber arms. Those are the guys you’re going to face when it matters. So, what I love about a series like this is, you were playing against a team that’s built to make a deep run into the playoffs -- and we played like one, too.” - Oliver Marmol after his team’s win against the Phillies in their game on Wednesday. 

“They got to his fastball, really. The three-run homers, in a game like that, that hit happens and with the way Cavalli’s pitching, it feels a little daunting. Ortiz had a nice game. He took some good swings this series. He’s a good young hitter.” - Craig Counsell after his team’s loss against the Nationals in their game on Thursday.

JJ Wetherholt (L) 2B

Iván Herrera (R) C

Alec Burleson (L) 1B

Jordan Walker (R) RF

Nathan Church (L) CF

Masyn Winn (R) SS

Bryan Torres (L) DH

José Fermín (R) LF

César Prieto (L) 3B

Pete Crow-Armstrong (L) CF

Seiya Suzuki (R) DH

Alex Bregman (R) 3B

Michael Busch (L) 1B

Nico Hoerner (R) 2B

Carson Kelly (R) C

Ian Happ (S) LF

Tyrone Taylor (R) RF

Dansby Swanson (R) SS

Batting Average:  Everson Pereira (.333)

Hits:  Alec Burleson (131)

Home Runs:  Jordan Walker (23)

RBI:  Jordan Walker (84)

Stolen Bases:  Jordan Walker (16)

Wins:  Andre Pallante (12)

Saves:  Riley O'Brien (30)

ERA:  Ryan Fernandez (2.70)

Batting Average:  Justin Dean (.375)

Hits:  Pete Crow-Armstrong (130)

Home Runs:  Pete Crow-Armstrong (27)

RBI:  Pete Crow-Armstrong (73)

Stolen Bases:  Pete Crow-Armstrong (30)

Wins:  Colin Rea (8)

Saves:  Jacob Webb (8)

ERA:  Ty Blach (0.00)

Managers:

St Louis Cardinals: Oliver Marmol (5th season)

Chicago Cubs: Craig Counsell (3rd season)