South Carolina Gamecocks vs Alabama Crimson Tide Prediction, Picks and Game Preview - 09/26/2026

Game Time: 7:00 pm ET, Saturday, September 26, 2026

Venue:  Bryant-Denny Stadium, Tuscaloosa, AL

Where to Watch:  ESPN

DraftKings:  Point Spread:  South Carolina +12.5, Alabama -12.5; Over/Under:  53.5 points

Bet365:  Point Spread:  South Carolina +12.5, Alabama -12.5; Over/Under:  53.5 points

BetMGM:  Point Spread:  South Carolina +12, Alabama -12; Over/Under:  53.5 points

South Carolina Gamecocks:  2-1 (0-1) (12th place, SEC)

Alabama Crimson Tide:  3-0 (1-0) (1st place, SEC)

Do not miss out on our expert handicapper analysis! Vegas Writer is on a HOT STREAK in college football on an 8-2 CFB RUN for +$5,800 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

South Carolina Gamecocks:  lost their last game at home against the Mississippi State Bulldogs 41-34.

Alabama Crimson Tide:  won their last game at home against the Florida State Seminoles 50-36.

South Carolina is entering this game with a 2-1 record overall and they have a 0-1 record in their conference games too. They are 2-1 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They lost their last game against Mississippi State 41-34. LaNorris Sellers was the starting QB and he completed 25/40 passes for 282 passing yards, 2 touchdowns, and 2 interceptions. Matt Fuller led the team in rushing yards with 73 and 1 TD. Matt Fuller led the receivers with 85 receiving yards on 7 receptions and 1 TD. Justin Okoronkwo led the defense in that game with 14 tackles while Vicari Swain and Anthony Addison each led the defense in sacks with 1. Peyton Williams came away with the only interception for them in that one.

 

 

 

Alabama is entering this game with a 3-0 record overall and they have a 1-0 record in their conference games too. They are 2-0 in their home games, 1-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Florida State 50-36. Keelon Russell was the starting QB and he completed 23/30 passes for 320 passing yards, 3 touchdowns, and 0 interceptions. Trae'shawn Brown led the team in rushing yards with 86 and 1 TD. Lotzeir Brooks led the receivers with 101 receiving yards on 8 receptions. Luke Metz and Devan Thompkins each led the defense in that game with 6 tackles while Devan Thompkins, Terrance Green, and Justin Hill each led the defense in sacks with 1. Red Morgan, Bray Hubbard, and Ivan Taylor each came away with 1 interception for them in that one.

The current betting odds have Alabama listed as a 12.5 point favorite in this game according to Draftkings Sportsbook. Alabama has looked great in their games this season with their 3-0 record overall and their 1-0 conference record which has them right near the top of the SEC. They have looked great on their home field too with their 2-0 home record this season. Meanwhile, South Carolina has looked good in their games this season with their 2-1 record overall, but their 0-1 conference record has them right near the bottom of the SEC. They haven't played any road games either and will be playing their 1st road game of the season here. South Carolina is coming off a 41-34 loss to Mississippi State at home and they blew a big lead in that game. They got out to a hot start with everything going right for them, but they managed to fold late on their own home field against one of the worst programs in the SEC over the last few years. Now they are playing their 1st road game of the year and the seat is starting to get hot for Shane Beamer, underperforming with a really talented QB. Alabama is coming off a 50-36 win over Florida State in their last one and their offense has been rolling this year. The defense didn't look great in that one, but the offense has looked a lot better this season with a more talented QB. They have had some slower starts in their last 2 games, needing to come from behind to win, but they are still trying to find their groove too. Now they are back at home and after another scare against a lesser Florida State team last week, they will be looking to come out stronger in this game and not put themselves in an early hole. Look for Alabama to come out rolling in this one and take advantage of a South Carolina defense that gives up a ton of points. The best way to place a bet here is on Alabama to cover the spread in this game. 

South Carolina Alabama Prediction:  Our NCAAF Pick for Saturday, September 26, 2026 (7:00 pm ET start time) is Alabama 38 South Carolina 20.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this South Carolina Gamecocks Alabama Crimson Tide prediction, be sure to drop by every day for our weekly NCAAF predictions and previews.

South Carolina Gamecocks: 34-22 ATS as an underdog of 10.5 to 21 points. 11-6 ATS off an upset loss to a conference rival as a home favorite. 7-2 ATS vs. good offensive  teams - scoring 31 or more points/game. 20-13 UNDER as a road underdog of 7.5 to 14 points. 13-6 UNDER off an upset loss to a conference rival as a favorite.

Alabama Crimson Tide: 22-31 ATS at home after a game with a turnover margin of +2 or better. 31-47 1H ATS when playing against a good team (Win Pct. 60% to 75%). 25-10 UNDER as a home favorite of 7.5 to 14 points. 15-7 UNDER off 3 or more consecutive overs.

South Carolina Gamecocks:  J. Peak (OG) Questionable - Undisclosed. L. Anderson III (QB) Questionable - Undisclosed. D. Stewart (DL) Out - Back. J. Sellers (WR) Out - Lower Body. J. Gibson (WR) Out - Lower Body.

Alabama Crimson Tide:  A. Walker (WR) Questionable - Undisclosed. N. Rogers (WR) Out - Leg. A. Dear (RB) Out - Leg.

“This moment won't define this football team. We will respond the right way.” - Shane Beamer after his team’s loss against Mississippi State in their last game. 

“Just a reminder, nothing from one week carries over to the next. Third down in particular, we got to get off the field. We have been great the first two weeks.” - Kalen DeBoer after his team’s win against FSU in their last game. 

WR Tuggle, Nitro

WR Harbor, Nyck

WR Bennett Jr., Mazeo

TE Hunt, Brady

QB Sellers, LaNorris

RB Fuller, Matt

WR Coleman-Williams, Ryan

WR Scott, Rico

WR Brooks, Lotzeir

TE Edwards, Kaleb

TE Pritchett, Marshall

QB Russell, Keelon

RB Hill, Daniel 

Passing: LaNorris Sellers (648)

Rushing: Matt Fuller (272)

Receiving: Donovan Murph (136)

Touchdowns: Matt Fuller (4)

Passing: Keelon Russell (764)

Rushing: Daniel Hill (210)

Receiving: Ryan Coleman-Williams (235)

Touchdowns: Daniel Hill (3)

Coaches:

South Carolina Gamecocks: Shane Beamer (6th season)

Alabama Crimson Tide: Kalen DeBoer (3rd season)