Philadelphia Phillies vs Arizona Diamondbacks Prediction, Preview and Odds - 09/02/2026

Game Time: 3:40 pm ET, Wednesday, September 2, 2026

Venue:  Chase Field, Phoenix, AZ

Where to Watch:  ESPN Unlimited, MLB TV

DraftKings:  Moneyline odds:  Phillies -115, Diamondbacks -105; Over/Under:  9 runs

Bet365:  Moneyline odds:  Phillies -115, Diamondbacks -105; Over/Under:  9 runs

BetMGM:  Moneyline odds:  Phillies -115, Diamondbacks -105; Over/Under:  9 runs

Philadelphia Phillies:  78-60 (2nd place, NL East)

Arizona Diamondbacks:  73-66 (3rd place, NL West)

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Philadelphia Phillies:  8-2 last 10

Arizona Diamondbacks:  5-5 last 10

The Phillies are entering this series off a win and completed the sweep in their 3-game series against the Los Angeles Angels 3-0 in their last series. They enter this game with a 78-60 record overall and have a road record of 40-30. This is the series finale of a 3-game series with the Diamondbacks on Wednesday with the 2nd game still to be played on Tuesday. The Phillies won the series opener on Monday. Their offense ranks 17th in the MLB with a .715 OPS. Jesús Luzardo is their starting pitcher on Tuesday while rookie pitcher Andrew Painter is making his start in this game on Wednesday. He is 3-8 with a 5.95 ERA this season. His team won their last 4 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 3 ER, 0 HR, and 3 BB with 6 SO on 2 hits through 6 IP against the Los Angeles Angels.

The Diamondbacks are entering this series off a loss and split their 4-game series against the San Francisco Giants 2-2 in their last series. They enter this game with a 73-66 record overall and have a home record of 40-30. This is the 3rd game of a 3-game series with the Phillies on Wednesday with the 2nd game of this series still to be played on Tuesday. The Diamondbacks lost the 1st game of this series on Monday. Their offense ranks 20th in the MLB with a .713 OPS. Eduardo Rodríguez is their starting pitcher on Tuesday while Taylor Clarke is making his start in this game on Wednesday. He is 2-3 with a 2.60 ERA this season. His team lost 3 of their last 4 games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 0 walks with 2 strikeouts on 0 hits through 1 inning pitched against the Philadelphia Phillies.

The current betting odds have the Phillies listed as a favorite in this game according to Draftkings Sportsbook. The Diamondbacks have looked good in their games this season with their 73-66 record overall which has them right in the middle of the NL West. They have looked great in their own ballpark too with their 40-30 home record this season. Meanwhile, the Phillies have looked really good in their games this season with their 78-60 record overall which has them right near the top of the NL East. They have been a good road team too with their 40-30 road record this year. The Diamondbacks are looking to get that last Wild Card spot in the NL, but lately they haven't looked great and have fallen out of that last spot. They are only 5-5 in their last 10 games while the Phillies have been rolling lately, going 8-2 in their last 10 games, and the Phillies are also fighting for that top Wild Card spot in the NL. The Phillies are going with Painter in this one and he hasn't looked good this season. He is 3-8 with a 5.95 ERA and he has been having a terrible rookie year, but lately he has looked a lot better. He did give up 3 earned runs in his last start, but that hasn't been a common theme for him over the last month and the team has been having a lot more success with him too, winning 4 games in a row now with him starting. The Diamondbacks aren't going to have their best option on the mound here, dealing with some injuries to their starting rotation, and their offense has also been really up and down lately too. The Phillies have all of the momentum on their side at the moment, so look for them to take advantage of this pitching matchup with Painter starting to improve. The best way to place a bet here is on the Phillies to win this game. 

Phillies Diamondbacks Prediction:  Our MLB Pick for Wednesday, September 2, 2026 (3:40 pm ET start time) is Phillies 6 Diamondbacks 4.

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Philadelphia Phillies: 123-113 (-9.9 units) on the moneyline in road games. 121-108 (-5 units) on the moneyline when playing against a team with a winning record. 80-75 (-21.6 units) on the moneyline in day games. 18-10 UNDER against NL West opponents.

Arizona Diamondbacks: 241-222 (+8.2 units) on the moneyline in all games. 122-118 (+19.6 units) on the moneyline when playing against a team with a winning record. 139-115 (+10.5 units) on the moneyline vs. an NL team with a team batting average of .255 or worse. 16-9 UNDER against NL East opponents.

Philadelphia Phillies:  F. Reyes (LF) Sixty Day IL - Wrist. C. Kilian (RP) Fifteen Day IL - Oblique. T. Banks (RP) Sixty Day IL - Forearm. R. Marchan (C) Ten Day IL - Knee. B. Keller (RP) Sixty Day IL - Elbow. J. Rojas (CF) Sixty Day IL - Elbow. A. Garcia (RF) Sixty Day IL - Lat.

Arizona Diamondbacks:  M. Soroka (SP) Fifteen Day IL - Arm. R. Thompson (RP) Fifteen Day IL - Back. Z. Gallen (SP) Sixty Day IL - Elbow. L. Gurriel Jr. (LF) Ten Day IL - Adductor. T. Troy (LF) Ten Day IL - Shoulder. R. Nelson (SP) Sixty Day IL - Elbow. B. Walston (SP) Sixty Day IL - Elbow. C. Mena (SP) Sixty Day IL - Shoulder. C. Burnes (SP) Sixty Day IL - Elbow. A. Puk (RP) Sixty Day IL - Elbow. A. Saalfrank (RP) Sixty Day IL - Shoulder.

“I think we have to win games and then we move on and try to win another game. Simple as that. You can't look past anybody. We have a rough schedule down the stretch, so I think [the mindset] is just: Win every day. I think that's the mode. It's what it should be. It's that time of year. It's the way you want to be. It's a day-to-day business at this point. You can't worry about tomorrow.” - Don Mattingly after his team’s win against the Diamondbacks in their game on Monday. 

"It's September. It's the best time of the year, and we're in this race. I know the standings flipped a little bit. It's going to be happening. It's going to happen the entire month. I think we're going to go out and play our finest month of baseball." - Torey Lovullo after his team’s loss against the Phillies in their game on Monday. 

Kyle Schwarber (L) DH

Trea Turner (R) SS

Bryce Harper (L) RF

Luis Arraez (L) 2B

Alec Bohm (R) 1B

Bryson Stott (L) 3B

Brandon Marsh (L) LF

Justin Crawford (L) CF

Garrett Stubbs (L) C

Geraldo Perdomo (S) SS

Corbin Carroll (L) RF

Gabriel Moreno (R) C

Ketel Marte (S) DH

Lars Nootbaar (L) LF

Nolan Arenado (R) 3B

Tim Tawa (R) 1B

Ildemaro Vargas (S) 2B

Ryan Waldschmidt (R) CF

Batting Average:  Bryan De La Cruz (.333)

Hits:  Trea Turner (132)

Home Runs:  Kyle Schwarber (40)

RBI:  Kyle Schwarber (82)

Stolen Bases:  Bryson Stott (23)

Wins:  Cristopher Sánchez (16)

Saves:  Jhoan Duran (29)

ERA:  Bryse Wilson (0.00)

Batting Average:  Gabriel Moreno (.303)

Hits:  Corbin Carroll (123)

Home Runs:  Ketel Marte (21)

RBI:  Ketel Marte (67)

Stolen Bases:  Corbin Carroll (20)

Wins:  Eduardo Rodriguez (14)

Saves:  Paul Sewald (24)

ERA:  Justin Martinez (0.00)

Managers:

Philadelphia Phillies: Don Mattingly (Interim)

Arizona Diamondbacks: Torey Lovullo (10th season)