Oregon Ducks vs Oklahoma State Cowboys Prediction, Picks and Game Preview - 09/12/2026

Game Time: 12:00 pm ET, Saturday, September 12, 2026

Venue:  Boone Pickens Stadium, Stillwater, OK 

Where to Watch:  ESPN, Disney+

DraftKings:  Point Spread:  Oregon -22.5, OK State +22.5; Over/Under:  57.5 points

Bet365:  Point Spread:  Oregon -22.5, OK State +22.5; Over/Under:  57.5 points

BetMGM:  Point Spread:  Oregon -22.5, OK State +22.5; Over/Under:  57.5 points

Oregon Ducks:  1-0 (0-0) (1st place, Big Ten)

Oklahoma State Cowboys:  0-1 (0-0) (14th place, Big 12)

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Oregon Ducks:  won their last game at home against the Boise State Broncos 34-27.

Oklahoma State Cowboys:  lost their last game on the road against the Tulsa Golden Hurricane 24-10.

Oregon is entering this game with a 1-0 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Boise State 34-27. Dante Moore was the starting QB and he completed 28/37 passes for 378 passing yards, 3 touchdowns, and 0 interceptions. Jordon Davison led the team in rushing yards with 90 and 1 TD. Jeremiah McClellan led the receivers with 150 receiving yards on 6 receptions and 1 TD. Koi Perich led the defense in that game with 11 tackles while Matayo Uiagalelei, Bear Alexander, and Teitum Tuioti each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

 

 

 

Oklahoma State is entering this game with a 0-1 record overall and they have a 0-0 record in their conference games too. They are 0-0 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against Tulsa 24-10. Drew Mestemaker was the starting QB and he completed 29/49 passes for 241 passing yards, 1 touchdown, and 2 interceptions. Caleb Hawkins led the team in rushing yards with 79. Wyatt Young led the receivers with 84 receiving yards on 8 receptions. Ethan Wesloski and Tate Romney each led the defense in that game with 7 tackles while no one on the defense recorded a sack for them. LaDainian Fields came away with the only interception for them in that one.

The current betting odds have Oregon listed as a 22.5 point favorite in this game according to Draftkings Sportsbook. Oregon has a 1-0 record overall this season and they beat a really good opponent in their season opener. They are coming off a 34-27 win over Boise State and they looked terrible in the 1st half as they were trailing for a lot of that game, but they looked like a different team in the 2nd half and did just enough to win the game. Boise State isn't a power 4 team, but they did make a playoff appearance 2 years ago and they have been one of the best group of 5 teams for years. That was a good win for Oregon and even though it was really close at times, they found a way to get the job done and will get better from that battle. They are ranked like one of the best teams in the nation and they are returning a ton of talent that made them one of the best last season too. Meanwhile, Oklahoma State has a 0-1 record overall this season and they aren't off to a good start in the Eric Morris era. Oklahoma State has been the bottom of the Big 12 for years with no real direction for their program and they finally hired a great coach in Eric Morris who brought a lot of players from that really good North Texas team last year. The talent hasn't really translated though, coming off a week 1 loss to Tulsa who isn't even a power 4 team. They lost 24-10 and couldn't do anything on offense which is all they had at North Texas last season. Oklahoma State is already in the dumps again after week 1 and they will be looking to bounce back here, but now they have one of the best teams in the nation coming into town and Oregon definitely isn't patting themselves on the back after that tight win last week. Oregon is going to bring their best effort here to right the ship after that tight game and show their dominance against an Oklahoma State team that was a complete disappointment in week 1. The best way to place a bet here is on Oregon to cover the spread in this game. 

Oregon Oklahoma State Prediction:  Our NCAAF Pick for Saturday, September 12, 2026 (12:00 pm ET start time) is Oregon 49 Oklahoma State 13.

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Oregon Ducks: 6-3 ATS when the total is between 56.5 and 63. 6-3 ATS in non-conference games. 11-4 ATS after playing a game at home. 24-18 OVER in a road game where the total is between 56.5 and 63.

Oklahoma State Cowboys: 7-16 ATS against FBS division opponents. 6-11 ATS as an underdog. 1-7 ATS when the total is between 56.5 and 63. 28-13 OVER in a home game where the total is between 56.5 and 63.

Oregon Ducks:  J. Lott (WR) Questionable - Undisclosed. I. Hooks (WR) Questionable - Undisclosed.

Oklahoma State Cowboys:  O. Hammond (TE) Questionable - Undisclosed. D. Green (TE) Questionable - Undisclosed. J. Sexton (OG) Questionable - Leg.

“We won the game with total yards and some situations, but we didn’t really win the critical situations. They won some of those critical situations. They played better in special teams than us today. They did better on fourth down. We kind of gave them an opportunity, a chance to hang around.” - Dan Lanning after his team’s win against BSU in their last game. 

"For a second year in a row, Tulsa, they reigned supreme on us right now on the football field. And that's a fact. I'm a fact guy, and I'm always going to tell you guys the way I feel.” - Eric Morris after his team’s loss against Tulsa in their last game. 

WR Moore, Dakorien

WR McClellan, Jeremiah

WR Stewart, Evan

TE Johnson, Jamari

QB Moore, Dante

RB Davison, Jordon

WR Bowick, Justin

WR Barnes, Chris

WR Young, Wyatt

TE Kolb, Carson

QB Mestemaker, Drew

RB Hawkins, Caleb

Passing: Dante Moore (378)

Rushing: Jordon Davison (90)

Receiving: Jeremiah McClellan (150)

Touchdowns: Jordon Davison (1)

Passing: Drew Mestemaker (241)

Rushing: Caleb Hawkins (79)

Receiving: Wyatt Young (84)

Touchdowns: Justin Bowick (1)

Coaches:

Oregon Ducks: Dan Lanning (5th season)

Oklahoma State Cowboys: Eric Morris (1st season)