Oklahoma State Cowboys vs Iowa State Cyclones Prediction, Picks and Game Preview - 10/31/2026

Game Time: 7:00 pm ET, Saturday, October 31, 2026

Venue:  Jack Trice Stadium, Ames, IA

Where to Watch:  FS1

DraftKings:  Point Spread:  OK State -9.5, ISU +9.5; Over/Under:  57.5 points

Bet365:  Point Spread:  OK State -9.5, ISU +9.5; Over/Under:  57.5 points

BetMGM:  Point Spread:  OK State -9, ISU +9; Over/Under:  57.5 points

Oklahoma State Cowboys:  5-2 (3-1) (5th place, Big 12)

Iowa State Cyclones:  3-4 (1-3) (13th place, Big 12)

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Oklahoma State Cowboys:  won their last game at home against the Colorado Buffaloes 57-24.

Iowa State Cyclones:  lost their last game on the road against the Arizona Wildcats 39-3.

Oklahoma State is entering this game with a 5-2 record overall and they have a 3-1 record in their conference games too. They are 4-0 in their home games, 1-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against Colorado 57-24. Drew Mestemaker was the starting QB and he completed 21/36 passes for 386 passing yards, 4 touchdowns, and 0 interceptions. Caleb Hawkins led the team in rushing yards with 120. Justin Bowick led the receivers with 138 receiving yards on 5 receptions and 1 TD. LaDainian Fields, Mo Horn, and Ethan Wesloski each led the defense in that game with 7 tackles while Ethan Wesloski led the defense in sacks with 2. LaDainian Fields came away with 2 interceptions for them in that one.

 

 

 

Iowa State is entering this game with a 3-4 record overall and they have a 1-3 record in their conference games too. They are 3-1 in their home games, 0-3 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against Arizona 39-3. Jaylen Raynor was the starting QB and he completed 8/10 passes for 106 passing yards, 0 touchdowns, and 0 interceptions. Aiden Flora led the team in rushing yards with 36. Vince Benetti led the receivers with 42 receiving yards on 3 receptions. Sullivan Schlimgen led the defense in that game with 15 tackles while Sullivan Schlimgen led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have Oklahoma State listed as a 9.5 point favorite in this game according to Draftkings Sportsbook. Oklahoma State has looked good in their games this season with their 5-2 record overall and their 3-1 conference record which has them in the top half of the Big 12. They haven't been a great road team though with their 1-2 road record this year. Meanwhile, Iowa State hasn't looked great in their games this season with their 3-4 record overall and their 1-3 conference record which has them in the bottom half of the Big 12. They have looked good on their home field though with their 3-1 home record this season. Iowa State has looked a lot better at home this season with their only home loss being against Utah who is still undefeated, but lately they haven't looked good in their games. They are coming off a 39-3 loss to Arizona in their last one and lately they have been getting blown out as their opponents have gotten tougher, their offense having a lot of trouble putting up points too. Oklahoma State has really turned things around this season with their new head coach and they have looked like one of the best teams in the conference all year. They have been in and out of the top 25 all season and they are coming off a 57-24 win over Colorado in their last one. They haven't had a great defense this season, but they have one of the best offenses in the Big 12 and that offense has been rolling lately with a ton of points being scored in their games. Iowa State is starting to look like the team that lost their head coach and half of their team at the end of last season and they just don't have the offensive talent to keep up with an offense like Oklahoma State has. The best way to place a bet here is on Oklahoma State to cover the spread in this game. 

Oklahoma State Iowa State Prediction:  Our NCAAF Pick for Saturday, October 31, 2026 (7:00 pm ET start time) is Oklahoma State 42 Iowa State 28.

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Oklahoma State Cowboys: 31-21 ATS after 3 or more consecutive wins against the spread. 31-18 ATS off a home blowout win by 28 points or more. 18-11 ATS off 3 or more consecutive overs. 37-23 UNDER as a road favorite. 13-5 UNDER on the road versus poor defensive teams - allowing 5.9 yards/play or more. 

Iowa State Cyclones: 11-22 ATS after 3 or more consecutive losses against the spread. 4-7 ATS vs. good offensive  teams - scoring 31 or more points/game. 2-6 ATS vs. good teams - outscoring opponents by 10+ PPG on the season. 17-4 UNDER after 3 or more consecutive losses against the spread. 13-5 UNDER off a road blowout loss by 28 points or more.

Oklahoma State Cowboys:  J. Sexton (OG) Out - Leg. O. Hammond (TE) Out - Undisclosed.

Iowa State Cyclones:  D. Overby (WR) Questionable - Knee. E. Miller (RB) Questionable - Undisclosed. L. Galer (TE) Questionable - Undisclosed. J. Singletary (CB) Questionable - Undisclosed. C. Crawford (DL) Questionable - Undisclosed. R. Barnes (TE) Questionable - Undisclosed. C. Pabst (WR) Out - Knee. J. Bailey (WR) Out - Undisclosed.

“I think any time you earn a right to play in the postseason, it’s big for your program. And I have not talked one time to my team about a bowl. I just haven’t. That’s not something that we set out to do. And where we’re at now, naturally it comes along with us having some success and us building this thing the right way.” - Eric Morris on his team becoming bowl eligible with a win against Iowa State this week. 

“They're good and we struggled. Not going to point the finger at one person, it's a collective group effort.” - Jimmy Rogers after his team’s loss against Arizona in their last game. 

WR Bowick, Justin

WR Lewis, Terrence

WR Coleman, Miles

TE Kolb, Carson

QB Mestemaker, Drew

RB Hawkins, Caleb

WR Overby, Dominic

WR Jackson, Cody

WR Hayes, Omari

TE Fortenberry, Tyler

QB Raynor, Jaylen

RB Flora, Aiden

Passing: Drew Mestemaker (2,326)

Rushing: Caleb Hawkins (712)

Receiving: Wyatt Young (639)

Touchdowns: Justin Bowick (7)

Passing: Jaylen Raynor (1,107)

Rushing: Aiden Flora (716)

Receiving: Omari Hayes (237)

Touchdowns: Aiden Flora (6)

Coaches:

Oklahoma State Cowboys: Eric Morris (1st season)

Iowa State Cyclones: Jimmy Rogers (1st season)