Oklahoma Sooners vs Michigan Wolverines Prediction, Picks and Game Preview - 09/12/2026

Game Time: 12:00 pm ET, Saturday, September 12, 2026

Venue:  Michigan Stadium, Ann Arbor, MI

Where to Watch:  FOX

DraftKings:  Point Spread:  Oklahoma -5.5, Michigan +5.5; Over/Under:  43.5 points

Bet365:  Point Spread:  Oklahoma -5.5, Michigan +5.5; Over/Under:  43.5 points

BetMGM:  Point Spread:  Oklahoma -5.5, Michigan +5.5; Over/Under:  43.5 points

Oklahoma Sooners:  1-0 (0-0) (1st place, SEC)

Michigan Wolverines:  1-0 (0-0) (1st place, Big Ten)

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Oklahoma Sooners:  won their last game at home against the UTEP Miners 51-0.

Michigan Wolverines:  won their last game at home against the Western Michigan Broncos 13-12.

Oklahoma is entering this game with a 1-0 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against UTEP 51-0. John Mateer was the starting QB and he completed 11/17 passes for 225 passing yards, 3 touchdowns, and 0 interceptions. Lloyd Avant led the team in rushing yards with 79 and 1 TD. Isaiah Sategna III led the receivers with 76 receiving yards on 4 receptions and 1 TD. Reggie Powers III and Owen Heinecke each led the defense in that game with 7 tackles while Dane Bathurst and Adepoju Adebawore each led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

 

 

 

Michigan is entering this game with a 1-0 record overall and they have a 0-0 record in their conference games too. They are 1-0 in their home games, 0-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against Western Michigan 13-12. Bryce Underwood was the starting QB and he completed 12/22 passes for 170 passing yards, 1 touchdown, and 1 interception. Bryce Underwood led the team in rushing yards with 47 and 1 TD. JJ Buchanan led the receivers with 126 receiving yards on 6 receptions and 1 TD. Dominic Nichols led the defense in that game with 2 tackles while Dominic Nichols led the defense in sacks with 1.5. No one on the defense came away with an interception for them in that one.

The current betting odds have Oklahoma listed as a 5.5 point favorite in this game according to Draftkings Sportsbook. Oklahoma has a 1-0 record overall this season and they destroyed a team from the FBS in their season opener. They beat UTEP 51-0 and the defense looked just as good as last season, if not better. They had one of the best defenses in the nation last year and they look like they are going to have one of the best defenses once again this season. Their offense did have a lot of trouble last year and didn't look great at times, but Mateer is healthy again and looked great in that offense. They put up a ton of points and were moving the ball with ease. Meanwhile, Michigan also has a 1-0 record overall this season, but they barely scraped by in their season opener. They are coming off a 13-12 win at home against Western Michigan and they were very fortunate to escape with the win from a last second hail mary. Western Michigan is definitely not a bad team, being the MAC champions last season, but they still don't have nearly as much talent as Michigan and still took them down to the wire. Now Michigan is getting a really big test with Oklahoma coming to town and Oklahoma looks like a team ready to compete for a National Championship this season while Michigan looks like a team that needs a lot more time to turn things around with their new head coach. Michigan played well on defense, but this is a stronger offense that they are going to be facing and their own offense had a lot of trouble against a weaker WMU defense, now taking on one of the best defenses in the nation. The best way to place a bet here is on Oklahoma to cover the spread in this game. 

Oklahoma Michigan Prediction:  Our NCAAF Pick for Saturday, September 12, 2026 (12:00 pm ET start time) is Oklahoma 31 Michigan 7.

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Oklahoma Sooners: 6-2 ATS in road lined games. 9-3 ATS when the total is between 42.5 and 49. 16-8 UNDER against FBS division opponents. 8-4 UNDER when the total is between 42.5 and 49. 

Michigan Wolverines: 10-17 ATS against FBS division opponents. 5-10 ATS in home lined games. 2-8 ATS in a home game where the total is between 42.5 and 49. 5-3 UNDER in non-conference games.

Oklahoma Sooners:  T. Blaylock (RB) Questionable - Hamstring.

Michigan Wolverines:  H. Hansen (TE) Questionable - Undisclosed.

"Yeah, we got a good group. A lot of them can do the same things, and then some of them are really good at, whether it's blocking or catching and things of that nature. I think that group has an opportunity to become one of the strengths of our football team, if they continue to develop that group as a whole. You saw, you know, Tryane Washington get extensive snaps, and we've been bragging on him for a couple of years. I know he was just a freshman last year. He's a high school wide receiver and DB, and now he's 260, you know, plus pounds, and he's playing fullback, h-back, playing in the wing, playing on the ball, and is a tremendous athlete. Really excited about you know that the depth and the versatility of that group." - Brent Venables after his team’s win against UTEP in their last game. 

“One for the history books right here." - Kyle Whittingham after his team’s win against WMU in their last game.  

WR Livingstone, Parker

WR Harris, Trell

WR Sategna III, Isaiah

TE Hansen, Hayden

QB Mateer, John

RB Robinson, Xavier

WR Marsh, Andrew

WR Goodwin, Channing

WR Buchanan, JJ

TE Marshall, Zack

QB Underwood, Bryce

RB Marshall, Jordan

Passing: John Mateer (225)

Rushing: Lloyd Avant (79)

Receiving: Isaiah Sategna III (76)

Touchdowns: Isaiah Sategna III (1)

Passing: Bryce Underwood (170)

Rushing: Bryce Underwood (47)

Receiving: JJ Buchanan (126)

Touchdowns: JJ Buchanan (1)

Coaches:

Oklahoma Sooners: Brent Venables (5th season)

Michigan Wolverines: Kyle Whittingham (1st season)