New York Yankees vs Chicago White Sox Prediction, Preview and Odds - 07/29/2026

Game Time: 7:40 pm ET, Wednesday, July 29, 2026

Venue:  Rate Field, Chicago, IL 

Where to Watch:  MLB TV, Prime Video, MLB Network

DraftKings:  Moneyline odds:  Yankees -143, White Sox +119; Over/Under:  7.5 runs

Bet365:  Moneyline odds:  Yankees -145, White Sox +120; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Yankees -145, White Sox +120; Over/Under:  8 runs

New York Yankees:  60-46 (2nd place, AL East)

Chicago White Sox:  55-50 (1st place, AL Central)

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New York Yankees:  6-4 last 10

Chicago White Sox:  5-5 last 10

The Yankees are entering this series off a loss and won their 3-game series against the Philadelphia Phillies 2-1 in their last series. They enter this game with a 60-46 record overall and have a road record of 34-23. This is the 3rd game of a 4-game series with the White Sox on Wednesday with the 2nd game still to be played on Tuesday. The Yankees won the series opener on Monday. Their offense ranks 9th in the MLB with a .731 OPS. Gerrit Cole is their starting pitcher on Tuesday while Cam Schlittler is making his start in this game on Wednesday. He is 10-6 with a 2.07 ERA this season. His team won 3 of their last 4 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 0 ER, 0 HR, and 0 BB with 12 SO on 3 hits through 7.1 IP against the Philadelphia Phillies.

The White Sox are entering this series off a win and lost their 3-game series against the Houston Astros 2-1 in their last series. They enter this game with a 55-50 record overall and have a home record of 32-20. This is the 3rd game of a 4-game series with the Yankees on Wednesday with the 2nd game of this series still to be played on Tuesday. The White Sox lost the 1st game of this series on Monday. Their offense ranks 11th in the MLB with a .729 OPS. Anthony Kay is their starting pitcher on Tuesday while Davis Martin is making his start in this game on Wednesday. He is 9-5 with a 3.49 ERA this season. His team lost their last 4 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 4 earned runs, 0 homers, and 0 walks with 3 strikeouts on 6 hits through 5 innings pitched against the Houston Astros.

The current betting odds have the Yankees listed as a favorite in this game according to Draftkings Sportsbook. The Yankees have looked good in their games this season with their 60-46 record overall which has them right near the top of the AL East. They have been a good road team too with their 34-23 road record this year. Meanwhile, the White Sox have looked good in their games this season with their 55-50 record overall which has them right at the top of the AL Central. They have looked great in their own ballpark too with their 32-20 home record this season. The White Sox have a top offense in the league this season, but they are only 5-5 in their last 10 games while the Yankees have been getting hot again, now 6-4 in their last 10 games, and they also have one of the best offenses in the league. Schlittler is on the mound for the Yankees in this one and he has looked great this season. He is 10-6 with a 2.07 ERA and he has been their ace this year. He is coming off another great start giving up no runs which has been a common theme for him and the team has been having a ton of success lately too, winning 3 of their last 4 games with him starting. The White Sox are going with Martin in this one and he has looked good this season. He is 9-5 with a 3.49 ERA and hasn't been giving up many runs all year, but lately he has been falling apart. He did give up 4 earned runs in his last start which has been a common theme lately and even his team has lost 4 games in a row now with him starting. The Yankees are going to be able to take advantage of this pitching matchup now that they are getting hot again. The best way to place a bet here is on the Yankees to win this game. 

Yankees White Sox Prediction:  Our MLB Pick for Wednesday, July 29, 2026 (7:40 pm ET start time) is Yankees 6 White Sox 2.

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New York Yankees: 68-28 (+26.8 units) on the moneyline against AL Central opponents. 131-96 (+10.8 units) on the moneyline in road games. 152-93 (+13.3 units) on the moneyline vs. an AL team with a slugging percentage of .410 or worse on the season. 26-13 UNDER as a road favorite of -110 or higher.

Chicago White Sox: 29-57 (-9.4 units) on the moneyline against AL East opponents. 156-273 (-56.8 units) on the moneyline in all games. 88-126 (-14.6 units) on the moneyline in home games. 25-19 UNDER at home when playing against a good team (Win Pct. 54% to 62%).

New York Yankees:  C. Bellinger (LF) Ten Day - Leg. A. Judge (RF) Sixty Day IL - Rib. C. Rodon (SP) Fifteen Day IL - Elbow. G. Stanton (DH) Ten Day IL - Leg. C. Schmidt (SP) Sixty Day IL - Elbow.

Chicago White Sox:  K. Teel (C) Ten Day IL - Ankle. T. Gilbert (RP) Fifteen Day IL - Shoulder. A. Hays (LF) Sixty Day IL - Calf. J. Leasure (RP) Sixty Day IL - Flexor. T. Murray (LF) Sixty Day IL - Shoulder. P. Berroa (RP) Sixty Day IL - Elbow. B. Baldwin (LF) Sixty Day IL - Elbow. M. Vasil (RP) Sixty Day IL - Elbow. D. Thorpe (SP) Sixty Day IL - Elbow. K. Bush (SP) Sixty Day IL - Elbow.

“We’ve got to play cleaner than that, but it was a really gritty effort by a lot of different people in that room.” - Aaron Boone after his team’s win against the White Sox in their game on Monday. 

“Yeah, he was in a really good spot there. The first three innings, all the strikeouts were full counts where they were really working him. Then there in the fourth, just a bunch of traffic. Thought it was time to move on.” - Will Venable on Noah Schultz after his team’s loss against the Yankees in their game on Monday. 

Max Schuemann (R) LF

Ben Rice (L) DH

Paul Goldschmidt (R) 1B

Jasson Domínguez (S) RF

Anthony Volpe (R) SS

Jazz Chisholm Jr. (L) 2B

José Caballero (R) 3B

Spencer Jones (L) CF

Ali Sánchez (R) C

Randal Grichuk (R) LF

Munetaka Murakami (L) 1B

Miguel Vargas (R) 3B

Colson Montgomery (L) DH

Chase Meidroth (R) 2B

Braden Montgomery (S) RF

Everson Pereira (R) CF

Edgar Quero (S) C

Luisangel Acuña (R) SS

Batting Average:  Ben Rice (.275)

Hits:  Ben Rice (104)

Home Runs:  Ben Rice (31)

RBI:  Ben Rice (73)

Stolen Bases:  Jazz Chisholm (29)

Wins:  Cam Schlittler (10)

Saves:  David Bednar (21)

ERA:  Yovanny Cruz (0.00)

Batting Average:  Sam Antonacci (.281)

Hits:  Chase Meidroth (104)

Home Runs:  Colson Montgomery (24)

RBI:  Miguel Vargas (63)

Stolen Bases:  Luisangel Acuña (15)

Wins:  Davis Martin (9)

Saves:  Seranthony Domínguez (12)

ERA:  Duncan Davitt (0.00)

Managers:

New York Yankees: Aaron Boone (9th season)

Chicago White Sox: Will Venable (2nd season)