LSU Tigers vs Kentucky Wildcats Prediction, Picks and Game Preview - 10/10/2026

Game Time: 7:00 pm ET, Saturday, October 10, 2026

Venue:  Kroger Field, Lexington, KY

Where to Watch:  ESPN

DraftKings:  Point Spread:  LSU -8.5, Kentucky +8.5; Over/Under:  51.5 points

Bet365:  Point Spread:  LSU -8.5, Kentucky +8.5; Over/Under:  51.5 points

BetMGM:  Point Spread:  LSU -8.5, Kentucky +8.5; Over/Under:  52.5 points

LSU Tigers:  4-1 (1-1) (8th place, SEC)

Kentucky Wildcats:  4-1 (2-1) (4th place, SEC)

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LSU Tigers:  won their last game at home against the McNeese State Cowboys 63-14.

Kentucky Wildcats:  won their last game on the road against the South Carolina Gamecocks 35-34 in overtime. 

LSU is entering this game with a 4-1 record overall and they have a 1-1 record in their conference games too. They are 4-0 in their home games, 0-1 in their road games, and they are also 0-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against McNeese State 63-14. Sam Leavitt was the starting QB and he completed 18/23 passes for 176 passing yards, 3 touchdowns, and 1 interception. Harlem Berry led the team in rushing yards with 125 and 1 TD. Corey Barber Jr. led the receivers with 83 receiving yards on 7 receptions and 2 TDs. Tylen Singleton led the defense in that game with 5 tackles while Deuce Geralds, Dominick McKinley, and Princewill Umanmielen each led the defense in sacks with 1. Tamarcus Cooley came away with the only interception for them in that one.

 

 

 

Kentucky is entering this game with a 4-1 record overall and they have a 2-1 record in their conference games too. They are 2-1 in their home games, 2-0 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They won their last game against South Carolina 35-34 in OT. Kenny Minchey was the starting QB and he completed 28/41 passes for 272 passing yards, 3 touchdowns, and 0 interceptions. CJ Baxter led the team in rushing yards with 48 and 1 TD. Kenny Darby led the receivers with 96 receiving yards on 12 receptions and 1 TD. Ty Bryant, Grant Godfrey, and Terhyon Nichols each led the defense in that game with 8 tackles while Grant Godfrey led the defense in sacks with 1. No one on the defense came away with an interception for them in that one.

The current betting odds have Kentucky listed as an 8.5 point underdog in this game according to Draftkings Sportsbook. Kentucky has looked good in their games this season with their 4-1 record overall and their 2-1 conference record which has them in the top half of the SEC. They have looked good on their home field too with their 2-1 home record this season. Meanwhile, LSU has looked good in their games this season with their 4-1 record overall and their 1-1 conference record which has them right in the middle of the SEC. They haven't been a great road team though with their 0-1 road record this year. LSU is coming off a 63-14 win over McNeese State in their last one and they have looked great at home this year with some blow out wins, but they looked very different in their only road game. That was their biggest challenge of the season and they failed, losing in Lane Kiffin's return to Ole Miss. They still have a ton of talent on their team and they do have the potential to be one of the best teams in the SEC, but Kentucky has also made some big strides this year with their new head coach. Their only loss was a bad one against Alabama, but they hung around in that game for a while before Alabama blew it open in the 4th quarter. Now they have won 2 games in a row and they have a ton of momentum on their side with both of those wins being upset wins. They are coming off a 35-34 win over South Carolina and managed to come back after being down by double digits. Kentucky definitely has an offense that can put up points at home and LSU hasn't really challenged yet other than their 1 road loss to Ole Miss. LSU should still get the win here, but Kentucky has the talent with this new head coach to keep this game tight at home. The best way to place a bet here is on Kentucky to cover the spread in this game. 

LSU Kentucky Prediction:  Our NCAAF Pick for Saturday, October 10, 2026 (7:00 pm ET start time) is LSU 34 Kentucky 30.

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LSU Tigers: 11-20 ATS in all lined games. 7-13 ATS as a favorite. 2-7 ATS when the total is between 49.5 and 56. 2-8 ATS when playing against a top-level team (Win Pct. > 75%). 7-3 UNDER in road lined games. 9-5 UNDER vs. good offensive  teams - scoring 31 or more points/game. 

Kentucky Wildcats: 6-1 ATS versus good rushing defenses - allowing 3.25 rushing yards/carry or less. 5-0 ATS vs. good defensive teams who give up 17 or less points/game. 5-0 ATS versus good defensive teams - allowing 4.5 yards/play or less. 29-22 UNDER versus good defensive teams - allowing 4.5 yards/play or less. 37-29 UNDER versus good defensive teams - allowing 310 yards/game or less. 

LSU Tigers:  T. Green (TE) Questionable - Undisclosed. T. Dottery (LB) Questionable - Undisclosed. R. Guillory Jr. (RB) Questionable - Undisclosed. P. Wright III (WR) Out - Undisclosed. D. Spears (S) Out - Knee.

Kentucky Wildcats:  L. Watkins (TE) Questionable - Undisclosed. D. Miller (WR) Questionable - Leg. T. Mizell (RB) Out - Undisclosed.

“Outside of a few plays late I thought our guys played really well. I know you are supposed to win these games big, but it doesn’t always happen. I thought our guys responded well particularly coming out of the locker room and played well in the third quarter. It was good to see a lot of guys make plays.” - Lane Kiffin after his team’s win against McNeese State in their last game. 

“We’re not perfect by any means. We’ve still got a lot of growth to do throughout the course of this season, but I do know our guys are the right people. They have the right mindset and makeup to go win football games in this league. So again, we got to continue to improve and embrace this grind. That is the SEC, but I know my guys fight.” - Will Stein after his team’s win against South Carolina in their last game. 

WR Harris, Jackson

WR Wilson III, Eugene

WR Watkins Jr., Winston

TE Green, Trey'Dez

QB Leavitt, Sam

RB Jones, Dilin

WR Miller, DJ

WR Anderson, Nic

WR Darby, Kenny

TE Rodriguez, Willie

QB Minchey, Kenny

RB Baxter, CJ

Passing: Sam Leavitt (1,221)

Rushing: Dilin Jones (426)

Receiving: Winston Watkins Jr. (354)

Touchdowns: Sam Leavitt (6)

Passing: Kenny Minchey (1,148)

Rushing: CJ Baxter (361)

Receiving: Kenny Darby (322)

Touchdowns: CJ Baxter (6)

Coaches:

LSU Tigers: Lane Kiffin (1st season)

Kentucky Wildcats: Will Stein (1st season)