Louisville Cardinals vs Mississippi Rebels Prediction, Picks and Game Preview - 09/06/2026

Game Time: 7:30 pm ET, Sunday, September 6, 2026

Venue:  Nissan Stadium, Nashville, TN 

Where to Watch:  ABC

DraftKings:  Point Spread:  Louisville +6.5, Ole Miss -6.5; Over/Under:  55.5 points

Bet365:  Point Spread:  Louisville +6.5, Ole Miss -6.5; Over/Under:  55.5 points

BetMGM:  Point Spread:  Louisville +6.5, Ole Miss -6.5; Over/Under:  55.5 points

Louisville Cardinals:  0-0 (0-0) (ACC)

Mississippi Rebels:  0-0 (0-0) (SEC)

Do not miss out on our expert handicapper analysis! Brian Bitler is coming off a HOT YEAR in CFB, going 85-56-4 for +$23,820 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Louisville Cardinals:  N/A

Mississippi Rebels:  N/A

Louisville finished last season with a 9-4 record overall and they had a 4-4 record in their conference games too.  They were 5-3 in their home games, 3-1 in their road games, and they were also 1-0 in their neutral site games last season where they will be for this season opener. Last season, their offense was averaging 29.9 points scored per game while their defense was allowing an average of 21.2 points per game. Their offense also averaged 384.5 yards per game while their defense was allowing an average of 303.1 yards per game. Miller Moss led the team in passing yards with 2,679, Isaac Brown led the team in rushing yards with 884, and Chris Bell led the team in receiving yards with 917.

 

 

 

Ole Miss finished last season with a 13-2 record overall and they had a 7-1 record in their conference games too.  They were 9-0 in their home games, 3-1 in their road games, and they were also 1-1 in their neutral site games last season where they will be for this season opener. Last season, their offense was averaging 36.9 points scored per game while their defense was allowing an average of 21.1 points per game. Their offense also averaged 489.7 yards per game while their defense was allowing an average of 348 yards per game. Trinidad Chambliss led the team in passing yards with 3,937, Kewan Lacy led the team in rushing yards with 1,567, and Harrison Wallace III led the team in receiving yards with 934.

The current betting odds have Louisville listed as a 6.5 point underdog in this game according to Draftkings Sportsbook. Louisville had a good season going 9-4 last year, but all 4 of their losses were against conference opponents and they didn't really have a great year in the ACC. Brohm has been building a solid program there over the last few years though and they had another great year of offense under Brohm. They definitely fell below expectations last season, but they are entering this year with a lot of high hopes. The conference isn't that strong this season so Louisville could be a team headed for the ACC Championship, and they don't have a tough schedule either. This is one of their toughest games this season, so they are going to bring their best effort to make a statement against an Ole Miss team that is a shell of its former self. Meanwhile, Ole Miss had a great season going 13-2 and ended up going to the CFP, but all of that was under Lane Kiffin. He did leave before the playoffs, but he built that team last season and they aren't going to have the same talent this year. They are returning their starting QB Chambliss who did have a great season and could be one of the best QB's in the nation this season, but they definitely downgraded with their head coach and could bottom out this year. Their offense is still going to be good with Chambliss leading the way, but their defense hasn't been good over the last few years and they aren't going to improve much this season either. Louisville has also had some issues on defense, so this could be a really high scoring game with 2 good offenses. Louisville has the talent on offense to put up points on this Ole Miss defense and they have the potential to pull off an upset in this game with the question marks surrounding Ole Miss this year. The best way to place a bet here is on Louisville to cover the spread in this game. 

Louisville Mississippi Prediction:  Our NCAAF Pick for Sunday, September 6, 2026 (7:30 pm ET start time) is Louisville 34 Ole Miss 30.

Don't miss our champion handicappers free picks and expert football picks today. And if you enjoyed this Louisville Cardinals Mississippi Rebels prediction, be sure to drop by every day for our weekly NCAAF predictions and previews.

Louisville Cardinals: 4-9 ATS as a neutral field underdog. 12-19 ATS in games played on a neutral field. 4-7 ATS on a neutral field where the total is between 49.5 and 56. 9-4 OVER as a neutral field underdog. 7-3 OVER in non-conference games.

Mississippi Rebels: 7-2 ATS against ACC opponents. 8-2 ATS as a neutral field favorite. 7-2 ATS on a neutral field where the total is between 49.5 and 56. 3-0 OVER on a neutral field where the total is between 49.5 and 56. 3-0 OVER in games played on a neutral field.

Louisville Cardinals:  M. Davis (RB) Questionable - Lower Body. M. Quisenberry (WR) Out - Lower Body. I. Brown (RB) Questionable - Undisclosed. K. Hughes (WR) Out - Lower Body.

Mississippi Rebels:  None.

“I was not real happy with the defense, so it is good that they struggled. They gave up way too many big plays. They had a couple of busts that really cost us. So, that needs to be fixed, but that is really fixable.” - Jeff Brohm on his team’s defense after their last scrimmage of fall camp. 

“(It) feels awesome. July was kind of that for me when we first spoke to get back into the ball piece of it, and then it was good to get through camp. Today’s the first day of class, and getting our guys ready for that routine and what that looks like for those guys.” - Pete Golding on entering the new college football season in his 1st year as head coach of Ole Miss. 

WR Hurry, TreyShun

WR McCoy, Lawayne

WR Richardson, Tre

TE Foley, Brody

QB Kienholz, Lincoln

RB Brown, Isaac

WR Alexander, Deuce

WR Gill Jr., Darrell

WR Cook II, Johntay

TE Hasz, Luke

QB Chambliss, Trinidad

RB Lacy, Kewan

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Coaches:

Louisville Cardinals: Jeff Brohm (4th season)

Mississippi Rebels: Pete Golding (1st season)