Indianapolis Colts vs Pittsburgh Steelers Prediction, Preview and Odds - 10/11/2026

Game Time: 1:00 pm ET, Sunday, October 11, 2026

Venue:  Acrisure Stadium, Pittsburgh, PA

Where to Watch:  CBS

DraftKings:  Point Spread:  Colts +2.5, Steelers -2.5; Over/Under:  44.5 points

Bet365:  Point Spread:  Colts +2.5, Steelers -2.5; Over/Under:  44.5 points

BetMGM:  Point Spread:  Colts +2.5, Steelers -2.5; Over/Under:  45 points

Indianapolis Colts:  2-2 (2nd place, AFC South)

Pittsburgh Steelers:  2-2 (3rd place, AFC North)

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Indianapolis Colts:  won their last game at a neutral site against the Washington Commanders 30-13.

Pittsburgh Steelers:  lost their last game on the road against the Cleveland Browns 27-24.

The Colts are entering this game with a 2-2 record overall and they have a 1-0 record in their divisional games too. They are 1-1 in their home games, 0-1 in their road games, and they are also 1-0 in their neutral site games this season, but they will be on the road for this game. They won their last game against the Washington Commanders 30-13. Daniel Jones was the starting QB and he completed 19/34 passes for 143 passing yards, 0 touchdowns, and 1 interception. Jonathan Taylor led the team in rushing yards with 95 and 2 TDs. Laquon Treadwell led the receivers with 42 receiving yards on 5 receptions. Akeem Davis-Gaither and Justin Walley each led the defense in that game with 8 solo tackles while Justin Walley led the defense in sacks with 1. Jaylon Carlies came away with the only interception for them in that one.

 

 

 

The Steelers are entering this game with a 2-2 record overall and they have a 1-1 record in their divisional games too. They are 2-0 in their home games, 0-2 in their road games, and they are also 0-0 in their neutral site games this season, but they will be at home for this game. They lost their last game against the Cleveland Browns 27-24. Aaron Rodgers was the starting QB and he completed 22/40 passes for 299 passing yards, 3 touchdowns, and 2 interceptions. Jaylen Warren led the team in rushing yards with 93. DK Metcalf led the receivers with 115 receiving yards on 5 receptions. Payton Wilson led the defense in that game with 9 solo tackles while Payton Wilson and T. J. Watt each led the defense in sacks with 1. Robert Spears-Jennings came away with the only interception for them in that one.

The current betting odds have the Steelers listed as a 2.5 point favorite in this game according to Draftkings Sportsbook. The Steelers haven't looked great in their games this season with their 2-1 record overall which has them right near the bottom of the AFC North. They have looked great on their home field though with their 2-0 home record this season. Meanwhile, the Colts haven't looked great in their games this season with their 2-2 record overall, but that record has them right near the top of the AFC South. They haven't been a great road team though with their 0-1 road record this year. The Colts had a bad start to the season going 0-2, but they really only had 1 bad game and have turned things around now. They looked terrible in week 1 against a really good Ravens team, but they almost beat the Chiefs the next week in a 33-30 loss in OT. Now they have some momentum on their side with 2 wins in a row and they are coming off a 30-13 win over the Commanders in their last one. As good as they have looked lately, they aren't in a great situation here since they played that game in England and are now on the road the next week. The Steelers haven't had a bad start to their season either and they will be looking to bounce back after a loss in prime time. They are coming off a 27-24 loss to the Browns in a game that they trailed most of the time, but now they are in a better situation here. They have looked a lot better in their 2 home games this season and they played that game against the Browns on Thursday, so they have had extra time to prepare and will bring their best effort to bounce back. They still have a ton of talent on defense to slow down this Colts offense that has been all Taylor carrying the team and the offense has looked a lot better in their home games too. Look for the Steelers to bounce back as the more rested team against a Colts team in a bad travel situation. The best way to place a bet here is on the Steelers to cover the spread in this game. 

Colts Steelers Prediction:  Our NFL Pick for Sunday, October 11, 2026 (1:00 pm ET start time) is Steelers 24 Colts 13.

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Indianapolis Colts: 28-39 ATS after 3 or more consecutive wins against the spread. 0-4 1H ATS after allowing 14 points or less last game. 1-4 1H ATS after a win by 14 or more points. 16-10 OVER in all games where the total is between 42.5 and 49 points. 16-10 OVER against conference opponents.

Pittsburgh Steelers: 7-2 ATS as a home favorite of 7 points or less. 9-4 ATS vs. bad defensive teams who give up 24 or more points/game. 10-5 ATS versus poor defensive teams - allowing 5.65 yards/play or more. 9-3 OVER versus poor rushing defenses - allowing 130 rushing yards/game or more. 

Indianapolis Colts:  G. Stewart (DL) Injured - Rest. C. Ward (CB) Injured - Rest. W. Mallory (TE) Injured - Thumb. J. Taylor (RB) Injured - Rest. K. Allen (WR) Injured - Rest. T. Bortolini (C) Injured - Ankle. J. Carlies (LB) Injured - Ribs. A. Davis-Gaither (LB) Injured - Knee. A. Dulin (WR) Injured - Hamstring. A. Key (DL) Injured - Hamstring.

Pittsburgh Steelers:  D. Elliott (S) Injured - Knee. J. Ramsey (CB) Injured - Wrist. C. Heyward (DL) Injured - NIR-Rest. J. Dean (CB) Injured - Ankle. M. Pittman Jr. (WR) Injured - Foot. R. Dowdle (RB) Injured - Toe.

“I had to show the world, hey, I had a really good tea.” - Jonathan Taylor after their win against the Commanders in their last game. 

“We had some protection challenges. It was a five-man pressure, man-to-man game. They established that right from the beginning. I think it was an aggressive game plan by them. I kind of expected some of it, and we were one play short.” - Mike McCarthy after his team’s loss against the Browns in their last game. 

WR Treadwell, Laquon

WR Dulin, Ashton

WR Downs, Josh

TE Warren, Tyler

QB Jones, Daniel

RB Taylor, Jonathan

WR Metcalf, DK

WR Pittman Jr., Michael

WR Wilson, Roman

TE Freiermuth, Pat

QB Rodgers, Aaron

RB Warren, Jaylen

FB Nowakowski, Riley

Passing: Daniel Jones (754)

Rushing: Jonathan Taylor (353)

Receiving: Josh Downs (202)

Touchdowns: Jonathan Taylor (6)

Passing: Aaron Rodgers (999)

Rushing: Jaylen Warren (309)

Receiving: DK Metcalf (213)

Touchdowns: Pat Freiermuth (2)

Coaches:

Indianapolis Colts: Shane Steichen (4th season)

Pittsburgh Steelers: Mike McCarthy (1st season)