Houston Astros vs Chicago White Sox Prediction, Preview and Odds - 07/25/2026

Game Time: 7:10 pm ET, Saturday, July 25, 2026

Venue:  Rate Field, Chicago, IL 

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Astros +104, White Sox -126; Over/Under:  8 runs

Bet365:  Moneyline odds:  Astros +105, White Sox -125; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Astros +105, White Sox -125; Over/Under:  8 runs

Houston Astros:  50-54 (3rd place, AL West)

Chicago White Sox:  54-47 (1st place, AL Central)

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Houston Astros:  4-6 last 10

Chicago White Sox:  7-3 last 10

The Astros are entering this series off a win and completed the sweep in their 3-game series against the Miami Marlins 3-0 in their last series. They enter this game with a 50-54 record overall and have a road record of 24-27. This is the 2nd game of a 3-game series with the White Sox on Saturday with the series opener still to be played on Friday. Their offense ranks 13th in the MLB with a .728 OPS. Spencer Arrighetti is their starting pitcher on Friday while Hunter Brown is making his start in this game on Saturday. He is 1-1 with a 4.05 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 4 ER, 0 HR, and 6 BB with 4 SO on 3 hits through 4.2 IP against the Baltimore Orioles.

The White Sox are entering this series off a win and won their 3-game series against the Texas Rangers 2-1 in their last series. They enter this game with a 54-47 record overall and have a home record of 31-17. This is the 2nd game of a 3-game series with the Astros on Saturday with the 1st game of this series still to be played on Friday. Their offense ranks 14th in the MLB with a .727 OPS. Davis Martin is their starting pitcher on Friday while Sean Burke is making his start in this game on Saturday. He is 7-4 with a 3.20 ERA this season. His team won their last 6 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 0 earned runs, 0 homers, and 1 walk with 5 strikeouts on 2 hits through 6.2 innings pitched against the Toronto Blue Jays.

The current betting odds have the White Sox listed as a slight favorite in this game according to Draftkings Sportsbook. The White Sox have looked good in their games this season with their 54-47 record overall which has them right at the top of the AL Central. They have looked great in their own ballpark too with their 31-17 home record this season. Meanwhile, the Astros haven't looked great in their games this season with their 50-54 record overall which has them right in the middle of the AL West. They haven't been a great road team either with their 24-27 road record this year. The Astros were rolling into the All-Star break, but now they are 4-6 in their last 10 games and have been falling apart lately, just when they got themselves back in the divisional race. The White Sox have been rolling though, now 7-3 in their last 10 games, and they have looked like a different team in their home games this year. The White Sox are going with Burke in this one and he has looked good this season. He is 7-4 with a 3.20 ERA and he has looked a lot better lately. He is coming off another great start in which he gave up no runs which has been a common theme for him lately, and the team has been having a ton of success with him too, winning 6 games in a row now with him starting. The Astros are going with Brown in this one and he hasn't looked great this year. He is 1-1 with a 4.05 ERA and he has missed some time this season due to injury. His team has lost 2 of their last 3 games with him starting and he is coming off a bad start in which he gave up 4 earned runs. The Astros have been really up and down lately while the White Sox have been rolling with a top offense in the league, so look for the White Sox to take advantage of this pitching matchup at home where they have looked so much better this season. The best way to place a bet here is on the White Sox to win this game. 

Astros White Sox Prediction:  Our MLB Pick for Saturday, July 25, 2026 (7:10 pm ET start time) is White Sox 9 Astros 3.

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Houston Astros: 80-73 (+25.7 units) on the moneyline as an underdog of +100 or higher. 105-97 (+6.4 units) on the moneyline when playing against a team with a winning record. 123-98 (+6.3 units) on the moneyline vs. an AL team with a slugging percentage .410 or worse on the season. 25-14 OVER when playing against a team with a winning record.

Chicago White Sox: 155-270 (-54.3 units) on the moneyline in all games. 87-123 (-12.1 units) on the moneyline in home games. 113-202 (-42.6 units) on the moneyline against right-handed starters. 43-25 OVER against right-handed starters.

Houston Astros:  B. Matthews (CF) Ten Day IL - Knee. M. Burrows (SP) Fifteen Day IL - Elbow. C. Correa (SS) Sixty Day IL - Ankle. H. Wesneski (RP) Sixty Day IL - Elbow. B. Walter (RP) Sixty Day IL - Elbow.

Chicago White Sox:  K. Teel (C) Ten Day IL - Ankle. E. Pereira (RF) Seven Day IL - Concussion. T. Gilbert (RP) Fifteen Day IL - Shoulder. A. Hays (LF) Sixty Day IL - Calf. J. Leasure (RP) Sixty Day IL - Flexor. T. Murray (LF) Sixty Day IL - Shoulder. P. Berroa (RP) Sixty Day IL - Elbow. B. Baldwin (LF) Sixty Day IL - Elbow. M. Vasil (RP) Sixty Day IL - Elbow. D. Thorpe (SP) Sixty Day IL - Elbow. K. Bush (SP) Sixty Day IL - Elbow.

“You get swept, you sweep somebody back, right? That’s a good bounceback win. That was good stuff. We bounced back very well against a good Marlins team. Beat one of the best pitchers in the game. I think our players, our team reacted very well after the way we played against Baltimore.” - Joe Espada after his team’s win against the Marlins in their game on Wednesday. 

“You've got to be able to execute pitches and continue to pound the zone, and they did that. Obviously, each one of them came out and did a great job.” - Will Venable after his team’s win against the Rangers in their game on Wednesday.

Jeremy Peña (R) SS

Yordan Alvarez (L) LF

Isaac Paredes (R) 3B

LaMonte Wade Jr. (L) RF

Yainer Diaz (R) DH

Christian Walker (R) 1B

Lucas Spence (L) CF

Nick Allen (R) 2B

Christian Vázquez (R) C

Sam Antonacci (L) LF

Munetaka Murakami (L) 1B

Miguel Vargas (R) 3B

Colson Montgomery (L) SS

Braden Montgomery (S) RF

Chase Meidroth (R) 2B

Andrew Benintendi (L) DH

Edgar Quero (S) C

Tristan Peters (L) CF

Batting Average:  Yordan Alvarez (.328)

Hits:  Yordan Alvarez (122)

Home Runs:  Yordan Alvarez (34)

RBI:  Yordan Alvarez (77)

Stolen Bases:  Cam Smith (10)

Wins:  Peter Lambert (8)

Saves:  Josh Hader (11)

ERA:  Miguel Ullola (0.00)

Batting Average:  Tristan Peters (.285)

Hits:  Chase Meidroth (101)

Home Runs:  Colson Montgomery (24)

RBI:  Miguel Vargas (61)

Stolen Bases:  Luisangel Acuña (15)

Wins:  Davis Martin (9)

Saves:  Seranthony Domínguez (12)

ERA:  Duncan Davitt (0.00)

Managers:

Houston Astros: Joe Espada (3rd season)

Chicago White Sox: Will Venable (2nd season)