Cleveland Guardians vs Minnesota Twins Prediction, Preview and Odds - 07/07/2026

Game Time: 7:40 pm ET, Tuesday, July 7, 2026

Venue:  Target Field, Minneapolis, MN 

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Guardians -101, Twins -120; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Guardians +100, Twins -120; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Guardians +100, Twins -120; Over/Under:  8.5 runs

Cleveland Guardians:  47-44 (2nd place, AL Central)

Minnesota Twins:  44-47 (3rd place, AL Central)

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Cleveland Guardians:  5-5 last 10

Minnesota Twins:  6-4 last 10

The Guardians are entering this series off a loss and split their 4-game series against the Chicago White Sox 2-2 in their last series. They enter this game with a 47-44 record overall and have a road record of 23-22. This is the series opener of a 3-game series with the Twins on Tuesday and they have Monday off as a day of rest. Their offense ranks 28th in the MLB with a .680 OPS. Tanner Bibee was their starting pitcher on Sunday while Joey Cantillo is making his start in this game on Tuesday. He is 7-3 with a 3.86 ERA this season. His team won 3 of their last 4 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 2 ER, 0 HR, and 5 BB with 4 SO on 3 hits through 5 IP against the Texas Rangers.

The Twins are entering this series off a win and won their 3-game series against the New York Yankees 2-1 in their last series. They enter this game with a 44-47 record overall and have a home record of 22-23. This is the 1st game of a 3-game series with the Guardians on Tuesday and they have Monday off as a day of rest. Their offense ranks 7th in the MLB with a .739 OPS. Joe Ryan was their starting pitcher on Sunday while Taj Bradley is making his start in this game on Tuesday. He is 7-3 with a 3.86 ERA this season. His team won their last 4 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 0 homers, and 3 walks with 11 strikeouts on 4 hits through 5 innings pitched against the Houston Astros.

The current betting odds have the Twins listed as a slight favorite in this game according to Draftkings Sportsbook. The Twins haven't looked good in their games this season with their 44-47 record overall which has them right in the middle of the AL Central. They haven't looked great in their own ballpark either with their 22-23 home record this season. Meanwhile, the Guardians have looked good in their games this season with their 47-44 record overall which has them right near the top of the AL Central. They have been a good road team too with their 23-22 road record this year. The Guardians just split their last series with the White Sox and they haven't looked great over the last 2 weeks, going 5-5 in their last 10 games too. The Twins have a lot of momentum on their side though as they are closing in on the divisional race, coming off a series win over the Yankees, and now they are 6-4 in their last 10 games. Bradley is on the mound for the Twins in this one and he has looked good this season. He is 7-3 with a 3.86 ERA and the team has had a ton of success with him this year. They have won 4 games in a row now with him starting and he is coming off another great start in which he gave up 1 earned run, something that has been becoming a common theme for him lately. The Guardians are going with Cantillo in this one and he has looked good this season too. He is 7-3 with a 3.86 ERA and he hasn't been giving up many runs lately either. He only gave up 2 earned runs in his last start and the team has won 3 of their last 4 games with him starting too, but the offense has also been a big issue for them. The Twins have been putting up a ton of runs lately while the Guardians haven't and the Twins do have a good offense this season while the Guardians have one of the worst in the league. Look for the Twins to use that better offense of theirs to their advantage now that they are back at home. The best way to place a bet here is on the Twins to win this game. 

Guardians Twins Prediction:  Our MLB Pick for Tuesday, July 7, 2026 (7:40 pm ET start time) is Twins 5 Guardians 3.

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Cleveland Guardians: 232-195 (+33.5 units) on the moneyline in all games. 109-103 (+22.7 units) on the moneyline in road games. 86-102 (+10.9 units) on the moneyline as an underdog of +100 or higher. 6-3 OVER vs. AL teams scoring 4.9 or more runs/game on the season.

Minnesota Twins: 196-219 (-45.4 units) on the moneyline in all games. 103-104 (-27.4 units) on the moneyline in home games. 117-103 (-26.3 units) on the moneyline as a favorite of -110 or higher. 33-15 OVER when the money line is +125 to -125.

Cleveland Guardians:  A. Martinez (LF) Ten Day IL - Foot. J. Ramirez (3B) Ten Day IL - Hand.

Minnesota Twins:  B. Buxton (CF) Day To Day - Hip. Z. Matthews (SP) Day To Day - Foot. A. Banda (RP) Fifteen Day IL - Lat. B. Ober (SP) Fifteen Day IL - Elbow. R. Jeffers (C) Ten Day IL - Hand. G. Acton (RP) Sixty Day IL - Shoulder. C. Sands (RP) Fifteen Day IL - Forearm. M. Abel (SP) Fifteen Day IL - Elbow. D. Festa (SP) Sixty Day IL - Shoulder. P. Lopez (SP) Sixty Day IL - Elbow.

“These are two very evenly matched teams. Obviously, maybe made up a little bit differently, but they're really good and so are we.” - Stephen Vogt after his team’s loss against the White Sox in their game on Sunday. 

“It was a different level. His ability to execute the fastball, to get the fastball in different quadrants. We know he’s got the low slot and the ride, but you could tell today there were a lot of uncomfortable swings, which I think was a testament to his stuff.” - Derek Shelton after his team’s win against the Yankees in their game on Sunday. 

Travis Bazzana (L) 2B

Kahlil Watson (L) CF

Chase DeLauter (L) RF

Kyle Manzardo (L) 1B

Gabriel Arias (R) 3B

Cooper Ingle (L) DH

Daniel Schneemann (L) SS

Patrick Bailey (S) C

Steven Kwan (L) LF

Austin Martin (R) LF

Byron Buxton (R) CF

Kody Clemens (L) 2B

Josh Bell (S) DH

Royce Lewis (R) 1B

Victor Caratini (S) C

Brooks Lee (S) 3B

Ryan Kreidler (R) SS

Luke Keaschall (R) RF

Batting Average:  Austin Hedges (.281)

Hits:  Brayan Rocchio (81)

Home Runs:  Angel Martínez (11)

RBI:  Chase DeLauter (41)

Stolen Bases:  José Ramírez (24)

Wins:  Gavin Williams (9)

Saves:  Cade Smith (26)

ERA:  Logan Allen (0.00)

Batting Average:  Gabriel Gonzalez (.500)

Hits:  Byron Buxton (83)

Home Runs:  Byron Buxton (25)

RBI:  Josh Bell (60)

Stolen Bases:  Luke Keaschall (12)

Wins:  Taj Bradley (7)

Saves:  Yoendrys Gómez (8)

ERA:  Kendry Rojas (1.65)

Managers:

Cleveland Guardians: Stephen Vogt (3rd season)

Minnesota Twins: Derek Shelton (1st season)