Cleveland Guardians vs Cincinnati Reds Prediction, Preview and Odds - 07/29/2026

Game Time: 7:10 pm ET, Wednesday, July 29, 2026

Venue:  Great American Ball Park, Cincinnati, OH

Where to Watch:  ESPN Unlimited, MLB TV

DraftKings:  Moneyline odds:  Guardians -135, Reds +112; Over/Under:  9 runs

Bet365:  Moneyline odds:  Guardians -135, Reds +115; Over/Under:  9 runs

BetMGM:  Moneyline odds:  Guardians -135, Reds +110; Over/Under:  9 runs

Cleveland Guardians:  54-53 (2nd place, AL Central)

Cincinnati Reds:  49-55 (5th place, NL Central)

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Cleveland Guardians:  3-7 last 10

Cincinnati Reds:  6-4 last 10

The Guardians are entering this series off a loss and got swept in their 3-game series against the Tampa Bay Rays 3-0 in their last series. They enter this game with a 54-53 record overall and have a road record of 27-27. This is the series finale of a 3-game series with the Reds on Wednesday with the series opener and the 2nd game still to be played on Tuesday in a double-header. Their offense ranks 30th in the MLB with a .680 OPS. Slade Cecconi is one of their starting pitchers on Tuesday while Joey Cantillo is making his start in this game on Wednesday. He is 8-6 with a 4.02 ERA this season. His team lost their last 2 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 5 ER, 1 HR, and 1 BB with 4 SO on 8 hits through 3.2 IP against the Tampa Bay Rays.

The Reds are entering this series off a win and won their 3-game series against the St Louis Cardinals 2-1 in their last series. They enter this game with a 49-55 record overall and have a home record of 22-28. This is the 3rd game of a 3-game series with the Guardians on Wednesday with the 1st game of this series and the 2nd game still to be played on Tuesday in a double-header. Their offense ranks 23rd in the MLB with a .705 OPS. Chase Burns is one of their starting pitchers on Tuesday while Brady Singer is making his start in this game on Wednesday. He is 5-9 with a 4.53 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 3 earned runs, 0 homers, and 1 walk with 6 strikeouts on 6 hits through 6.2 innings pitched against the Seattle Mariners.

The current betting odds have the Guardians listed as a favorite in this game according to Draftkings Sportsbook. The Guardians have looked good in their games this season with their 54-53 record overall which has them right near the top of the AL Central. They haven't been a great road team though with their 27-27 road record this year. Meanwhile, the Reds haven't looked great in their games this season with their 49-55 record overall which has them right at the bottom of the NL Central. They haven't looked good in their own ballpark either with their 22-28 home record this season. The Guardians have looked terrible lately, now 3-7 in their last 10 games, while the Reds are 6-4 in their last 10 games and have been getting hot, but the Guardians do have the better pitching matchup in this one. The Guardians are going with Cantillo in this one and he hasn't looked great this season. He is 8-6 with a 4.02 ERA and he has been really up and down this season. He just gave up 5 earned runs in his last start and the team has lost 2 games in a row now with him starting, but that hasn't been a common theme for him all season. The Reds are also going with Singer in this one and he hasn't looked any better this year. He is 5-9 with a 4.53 ERA and he has been giving up quite a few runs all year. He gave up 3 earned runs in his last start and that has been a common theme for him. The Guardians have been a solid team all season and they are going to be desperate to get back on track with the better pitching matchup here. The bullpens are also going to take a hit from the double-header on Tuesday, so the Guardians have the edge there too. The best way to place a bet here is on the Guardians to win this game. 

Guardians Reds Prediction:  Our MLB Pick for Wednesday, July 29, 2026 (7:10 pm ET start time) is Guardians 6 Reds 5.

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Cleveland Guardians: 239-204 (+30.8 units) on the moneyline in all games. 113-108 (+22.2 units) on the moneyline in road games. 137-86 (+19.8 units) on the moneyline as a favorite of -110 or higher. 28-20 UNDER against NL Central opponents. 

Cincinnati Reds: 208-221 (-7.6 units) on the moneyline in all games. 105-106 (-17.6 units) on the moneyline in home games. 80-106 (-11.3 units) on the moneyline as an underdog of +100 to +150. 39-25 UNDER as a home underdog of +100 or higher. 

Cleveland Guardians:  S. Armstrong (RP) Fifteen Day IL - Leg.

Cincinnati Reds:  S. Steer (1B) Ten Day - Hand. N. Lodolo (SP) Fifteen Day IL - Finger. M. McLain (2B) Ten Day IL - Calf. B. Dunn (CF) Ten Day IL - Elbow. T. Santillan (RP) Fifteen Day IL - Oblique. G. Ashcraft (RP) Sixty Day IL - Forearm. B. Williamson (SP) Sixty Day IL - Shoulder.

“The Rays really didn’t get anything going outside of manufacturing a run. You tip your cap to them. That’s what you have to do against pitchers like [Messick]. He was so outstanding today. That was as impressive as we’ve seen Parker all year.’’ - Stephen Vogt after his team’s loss against the Rays in their game on Sunday. 

“He didn’t fight me to come out of that game. That makes me nervous. We’ll get him looked at, we’ll get him imaged, and then they’re setting up an appointment with the hand specialist.” - Terry Francona on Spencer Steer after his team’s win against the Cardinals in their game on Sunday. 

Steven Kwan (L) LF

José Ramírez (S) 3B

Chase DeLauter (L) DH

Travis Bazzana (L) 2B

Brayan Rocchio (S) SS

Kyle Manzardo (L) 1B

Angel Martínez (S) RF

Patrick Bailey (S) C

Petey Halpin (L) CF

Elly De La Cruz (S) SS

Sal Stewart (R) 1B

JJ Bleday (L) RF

Eugenio Suárez (R) 3B

Nathaniel Lowe (L) DH

Tyler Stephenson (R) C

Dane Myers (R) CF

Edwin Arroyo (S) 2B

TJ Friedl (L) LF

Batting Average:  Chase DeLauter (.282)

Hits:  Brayan Rocchio (97)

Home Runs:  Angel Martínez (11)

RBI:  Chase DeLauter (50)

Stolen Bases:  José Ramírez (24)

Wins:  Gavin Williams (10)

Saves:  Cade Smith (29)

ERA:  Franco Aleman (1.54)

Batting Average:  Blake Dunn (.282)

Hits:  Sal Stewart (100)

Home Runs:  Sal Stewart (21)

RBI:  Sal Stewart (76)

Stolen Bases:  Elly De La Cruz (18)

Wins:  Chase Burns (12)

Saves:  Emilio Pagán (10)

ERA:  Tejay Antone (2.25)

Managers:

Cleveland Guardians: Stephen Vogt (3rd season)

Cincinnati Reds: Terry Francona (2nd season)