Cleveland Browns vs Jacksonville Jaguars Prediction, Preview and Odds - 09/13/2026

Game Time: 1:00 pm ET, Sunday, September 13, 2026

Venue:  EverBank Stadium, Jacksonville, FL

Where to Watch:  CBS

DraftKings:  Point Spread:  Browns +7.5, Jaguars -7.5; Over/Under:  40.5 points

Bet365:  Point Spread:  Browns +7.5, Jaguars -7.5; Over/Under:  40.5 points

BetMGM:  Point Spread:  Browns +8, Jaguars -8; Over/Under:  40.5 points

Cleveland Browns:  0-0 (AFC North)

Jacksonville Jaguars:  0-0 (AFC South)

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Cleveland Browns:  N/A

Jacksonville Jaguars:  N/A

The Browns finished last season with a 5-12 record overall and they were 2-4 in their division games too. They had a 3-6 record in their home games and had a 2-6 record in their road games where they will be in this game. Last season, their offense was averaging 16.4 points per game and their defense was allowing an average of 22.3 points per game. Their offense was also averaging 262.1 yards per game and their defense was allowing an average of 283.6 yards per game. Shedeur Sanders led the team in passing yards with 1,400, Quinshon Judkins led the team in rushing yards with 827, and Harold Fannin led the team in receiving yards with 731.

The Jaguars finished last season with a 13-4 record overall and they were 5-1 in their division games too. They had a 7-2 record in their home games and had a 6-2 record in their road games where they will be in this game. Last season, their offense was averaging 27.9 points per game and their defense was allowing an average of 19.8 points per game. Their offense was also averaging 337.4 yards per game and their defense was allowing an average of 303.6 yards per game. Trevor Lawrence led the team in passing yards with 4,007, Travis Etienne led the team in rushing yards with 1,107, and Parker Washington led the team in receiving yards with 847.

The current betting odds have the Jaguars listed as a 7.5 point favorite in this game according to Draftkings Sportsbook. The Jaguars had a great season going 13-4 overall and winning the AFC South. They had a great defense that caused a lot of turnovers and they will be looking to improve this season with Liam Coen entering his 2nd year coaching the team. They have a lot of talent on offense too and Trevor Lawrence is coming off a great season, looking to build on that in year 2 of this system. Meanwhile, the Browns had a terrible season going 5-12 overall and they were one of the worst teams in the NFL. They did have a really good defense that kept them in a lot of games and they still have a lot of young talent on that defense entering this season, but they also traded away their best player in the off-season and will definitely take a step back because of it. They have a lot of young talent on offense too, but they just don't have a solid starting QB and that is going to be an issue for them all season. Deshaun Watson is going to be the starting QB, but he hasn't played a full season in the NFL in years. He has been dealing with a lot of injuries over the last few years and he has dealt with a lot of issues off the field too. Once again, the Browns have potential all over their roster, but the QB situation is going to be something that holds them back all year and the offense definitely won't be on the same page here in their 1st game with a new head coach now. The Jags are looking to build off a great season last year and should take care of the Browns easily in this home opener. The best way to place a bet here is on the Jaguars to cover the spread in this game. 

Browns Jaguars Prediction:  Our NFL Pick for Sunday, September 13, 2026 (1:00 pm ET start time) is Jaguars 28 Browns 13.

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Cleveland Browns: 12-22 ATS in all games. 4-13 ATS in road games. 3-7 ATS in a road game where the total is between 35.5 and 42 points. 13-6 UNDER as an underdog of 3.5 to 9.5 points. 

Jacksonville Jaguars: 21-12 ATS in all games. 10-5 ATS in home games. 8-4 ATS as a favorite. 35-20 UNDER at home against AFC North division opponents.

Cleveland Browns:  None.

Jacksonville Jaguars:  None.

“You’re not deaf to the noise, right, obviously what you hear. But you try to tune that out and try to focus on what you see every day and what the player brings every day.” - Todd Monken on picking Deshaun Watson as the starting QB.

"I think just being him, like being the best version of himself. I mean, when you try to sometimes do too much, or you've been in multiple systems, and now even in Year 2 of our system, you may look to do too many different things. And when Trevor keeps it simple, goes through a read, and then 'Hey, man, he doesn't like it.' He has the opportunity in athleticism to use his legs as a weapon.” - Liam Coen on Trevor Lawrence coming into this new NFL season. 

WR Boston, Denzel

WR Jeudy, Jerry

WR Concepcion, KC

TE Fannin Jr., Harold

QB Watson, Deshaun

RB Judkins, Quinshon

FB Burton, Michael

WR Thomas Jr., Brian

WR Meyers, Jakobi

WR Washington, Parker

TE Strange, Brenton

QB Lawrence, Trevor

RB Tuten, Bhayshul 

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Passing: N/A

Rushing: N/A

Receiving: N/A

Touchdowns: N/A

Coaches:

Cleveland Browns: Todd Monken (1st season)

Jacksonville Jaguars: Liam Coen (2nd season)