Chicago White Sox vs Houston Astros Prediction, Preview and Odds - 09/01/2026

Game Time: 8:10 pm ET, Tuesday, September 1, 2026

Venue:  Daikin Park, Houston, TX

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  White Sox -123, Astros +102; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  White Sox -120, Astros +100; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  White Sox -120, Astros +100; Over/Under:  8.5 runs

Chicago White Sox:  72-64 (1st place, AL Central)

Houston Astros:  69-68 (1st place, AL West)

Do not miss out on our expert handicapper analysis! Brian Bitler is on a HOT STREAK in MLB on an 8-2 MLB RUN for +$6,230 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Chicago White Sox:  6-4 last 10

Houston Astros:  5-5 last 10

The White Sox are entering this series off a loss and won their 3-game series against the Minnesota Twins 2-1 in their last series. They enter this game with a 72-64 record overall and have a road record of 31-37. This is the 2nd game of a 4-game series with the Astros on Tuesday with the series opener still to be played on Monday. Their offense ranks 8th in the MLB with a .728 OPS. Anthony Kay is their starting pitcher on Monday while Sean Burke is making his start in this game on Tuesday. He is 7-6 with a 3.32 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 2 ER, 1 HR, and 8 BB with 3 SO on 2 hits through 3 IP against the Texas Rangers.

The Astros are entering this series off a win and won their 3-game series against the New York Mets 2-1 in their last series. They enter this game with a 69-68 record overall and have a home record of 33-35. This is the 2nd game of a 4-game series with the White Sox on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 9th in the MLB with a .726 OPS. Peter Lambert is their starting pitcher on Monday while Ronel Blanco is making his start in this game on Tuesday. He is 0-1 with a 7.71 ERA this season. His team won 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 5 earned runs, 1 homer, and 1 walk with 3 strikeouts on 7 hits through 4 innings pitched against the Seattle Mariners.

The current betting odds have the Astros listed as a slight underdog in this game according to Draftkings Sportsbook. The Astros have looked good in their games this season with their 69-68 record overall which has them right at the top of the AL West. They haven't looked great in their own ballpark though with their 33-35 home record this season. Meanwhile, the White Sox have looked good in their games this season with their 72-64 record overall which has them right at the top of the AL Central. They haven't been a good road team though with their 31-37 road record this year. The White Sox have looked good lately as they are 6-4 in their last 10 games while the Astros are 5-5 in their last 10 games and have been up and down lately. The Astros are still leading their division though and they are starting to break out of a huge slump that they were in. They are going to be motivated to win this series back at home after having a terrible homestand just over a week ago, but their pitching has looked a lot better lately and they will be able to take advantage of this pitching matchup. The White Sox are going with Burke in this one and he has looked good this season. He is 7-6 with a 3.32 ERA and he hasn't been giving up many runs lately. He only gave up 2 earned runs in his last start and the team has won 3 games in a row now with him starting too, but the bullpen has also been a big issue for them. The Astros are going to have the edge at home with the better pitching staff and the White Sox haven't looked nearly as good in their road games either. The best way to place a bet here is on the Astros to win this game. 

White Sox Astros Prediction:  Our MLB Pick for Tuesday, September 1, 2026 (8:10 pm ET start time) is Astros 3 White Sox 1.

Don't miss our champion handicappers free picks, best bets, and expert baseball picks today.  And if you enjoyed this Chicago White Sox Houston Astros prediction, be sure to drop by every day for our daily MLB projections and previews.

Chicago White Sox: 173-287 (-52.8 units) on the moneyline in all games. 76-154 (-39.5 units) on the moneyline in road games. 127-212 (-37.4 units) on the moneyline against right-handed starters. 16-10 OVER against AL West opponents.

Houston Astros: 137-108 (+5.6 units) on the moneyline vs. an AL team with a slugging percentage .410 or worse on the season. 111-101 (+9.4 units) on the moneyline when playing against a team with a winning record. 161-138 (+14.2 units) on the moneyline vs. a team with a good bullpen whose WHIP is 1.350 or better. 31-17 OVER when playing against a team with a winning record.

Chicago White Sox:  H. Brazoban (RP) Fifteen Day IL - Lat. D. Martin (SP) Fifteen Day IL - Finger. C. Murphy (RP) Fifteen Day IL - Flexor. J. Bart (C) Ten Day IL - Hand. K. Teel (C) Ten Day IL - Ankle. J. Leasure (RP) Sixty Day IL - Flexor. T. Murray (LF) Sixty Day IL - Shoulder. P. Berroa (RP) Sixty Day IL - Elbow. B. Baldwin (LF) Sixty Day IL - Elbow. M. Vasil (RP) Sixty Day IL - Elbow. D. Thorpe (SP) Sixty Day IL - Elbow. K. Bush (SP) Sixty Day IL - Elbow.

Houston Astros:  B. Matthews (CF) Sixty Day IL - Knee. M. Burrows (SP) Fifteen Day IL - Elbow. C. Correa (SS) Sixty Day IL - Ankle. B. Walter (RP) Sixty Day IL - Elbow.

“You come here to win a series, we won the series. Obviously, today was very disappointing, just not being able to get the offense going. A tough first inning for us on the mound and on defense. But we won a series and we move on.” - Will Venable after his team’s loss against the Twins in their game on Sunday. 

“I thought we needed to come out after our homestand, get back up and play good baseball, and I thought we did. Now my message to them is not to get complacent. We have two really good teams coming to Houston and we have to continue to play well. But I’m really proud of our effort. We took care of business on the mound, [had] big hits and [were] just picking each other up. I’m proud of our effort. It’s been fun to watch.” - Joe Espada after his team’s win against the Mets in their game on Sunday. 

Sam Antonacci (L) 2B

Munetaka Murakami (L) 1B

Miguel Vargas (R) 3B

Andrew Benintendi (L) DH

Braden Montgomery (S) RF

Colson Montgomery (L) SS

Tristan Peters (L) LF

Brenton Doyle (R) CF

Drew Romo (S) C

Jeremy Peña (R) SS

Yordan Alvarez (L) LF

Isaac Paredes (R) DH

Jose Altuve (R) 2B

Christian Walker (R) 1B

Daulton Varsho (L) CF

Yainer Diaz (R) C

Cam Smith (R) RF

Nick Allen (R) 3B

Batting Average:  Randal Grichuk (.290)

Hits:  Chase Meidroth (131)

Home Runs:  Munetaka Murakami (29)

RBI:  Miguel Vargas (76)

Stolen Bases:  Sam Antonacci (17)

Wins:  Davis Martin (9)

Saves:  Seranthony Domínguez (12)

ERA:  Hagen Smith (0.82)

Batting Average:  Yordan Alvarez (.317)

Hits:  Yordan Alvarez (154)

Home Runs:  Yordan Alvarez (37)

RBI:  Yordan Alvarez (93)

Stolen Bases:  Cam Smith (10)

Wins:  Peter Lambert (8)

Saves:  Josh Hader (21)

ERA:  Josh Hader (0.74)

Managers:

Chicago White Sox: Will Venable (2nd season)

Houston Astros: Joe Espada (3rd season)