Big Al's Daily Angle: MLB Previews and Odds - 09/15/26

by Big Al Staff

Tuesday, Sep 15, 2026
The Tuesday sports card features MLB action. 

Major League Baseball has 15 games scheduled. Four MLB games throw out the first pitch at 6:40 p.m. ET. Cleveland hosts Chicago with the Guardians sending out Foster Griffin to pitch against the White Sox’s Davis Martin. The Guardians are a -130 money-line favorite with the total set at 8.5 (all odds from DraftKings, unless indicated otherwise). Milwaukee travels to Pittsburgh with Jacob Misiorowski taking the ball for the Brewers to duel against Lake Bachar for the Pirates. The Brewers are a -257 money-line road favorite with an over/under of 7.5. Tampa Bay plays at home against the Athletics, with the Rays turning to Griffin Jax to take on Jack Perkins. The Rays are a -231 money-line favorite with a total of 8. Los Angeles plays in Cincinnati with Yoshinobu Yamamoto taking the mound for the Dodgers to battle the Rhett Lowder for the Reds. The Dodgers are a -217 money-line road favorite with an over/under of 8.5. 

The Philadelphia Phillies are on the road to challenge the Washington Nationals at 6:45 p.m. ET. The Phillies tap Christopher Sanchez to take the ball to pitch against the Nationals’ Jackson Kent. Philadelphia is a -217 money-line road favorite with a total of 8. 

The Toronto Blue Jays are at home to face the Detroit Tigers at 7:07 p.m. ET. Brandon Fisher gets the starting assignment for the Blue Jays to duel against Drew Anderson for the Tigers. Toronto is a -143 money-line favorite with an over/under of 8.5.

The New York Mets host the Baltimore Orioles at 7:10 p.m. ET. The Mets send out Sean Manaea to challenge the Orioles’ Shane Baz. New York is a -131 money-line favorite with a total of 8. 

Two MLB games begin at 7:40 p.m. ET. New York visits Minnesota with Max Fried getting the ball for the Yankees to battle Bailey Ober for the Twins. The Yankees are a -180 money-line road favorite with an over/under of 8. Chicago plays at home against Atlanta on TBS with the Cubs tapping Kevin Gausman to battle against the Braves’ Martin Perez. The Cubs are a -143 money-line favorite with a total of 8.5. 

The St. Louis Cardinals are at home to play the San Francisco Giants at 7:45 p.m. ET. Andre Pallante takes the mound for the Cardinals to pitch against Blake Tidwell for the Giants. St. Louis is a -168 money-line favorite with an over/under of 8. 

The Boston Red Sox play in Texas against the Rangers at 8:05 p.m. ET. The Red Sox turn to Patrick Sandoval to take on a Rangers starting pitcher yet to be named. Boston is a -125 money-line road favorite on the consensus line. 

The Houston Astros host the Kansas City Royals at 8:10 p.m. ET. Hunter Brown gets the ball for the Astros to face Michael Wacha for the Royals. Houston is a -167 money-line favorite with a total of 8. 

The San Diego Padres are on the road in Colorado to take on the Rockies at 8:40 p.m. ET. The Padres tap Walker Buehler to duel against the Rockies’ Kyle Freeland. San Diego is a -197 money-line road favorite with an over/under of 11.5. 

The Seattle Mariners travel to Los Angeles to play the Angels at 9:38 p.m. ET. Logan Gilbert takes the mound for the Mariners to challenge Ryan Johnson for the Angels. Seattle is a -170 money-line road favorite with a total of 8. 

The Arizona Diamondbacks play at home against the Miami Marlins at 9:40 p.m. ET. The Diamondbacks turn to Michael Soroka to battle the Marlins Janson Junk. Arizona is a -157 money-line favorite with an over/under of 8.5.

All photographic images used for editorial content have been licensed from the Associated Press.

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