Baltimore Orioles vs Minnesota Twins Prediction, Preview and Odds - 08/12/2026

Game Time: 1:40 pm ET, Wednesday, August 12, 2026

Venue:  Target Field, Minneapolis, MN

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Orioles +100, Twins -120; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Orioles +100, Twins -120; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Orioles +100, Twins -120; Over/Under:  8.5 runs

Baltimore Orioles:  57-62 (4th place, AL East)

Minnesota Twins:  59-61 (2nd place, AL Central)

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Baltimore Orioles:  4-6 last 10

Minnesota Twins:  4-6 last 10

The Orioles are entering this series off a win and lost their 3-game series against the Texas Rangers 2-1 in their last series. They enter this game with a 57-62 record overall and have a road record of 25-32. This is the series finale of a 3-game series with the Twins on Wednesday with the 2nd game still to be played on Tuesday. The Orioles lost the series opener on Monday. Their offense ranks 19th in the MLB with a .712 OPS. Brandon Young is their starting pitcher on Tuesday while Shane Baz is making his start in this game on Wednesday. He is 4-11 with a 3.76 ERA this season. His team lost their last 4 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 2 ER, 1 HR, and 1 BB with 9 SO on 3 hits through 8 IP against the Texas Rangers.

The Twins are entering this series off a loss and lost their 3-game series against the Milwaukee Brewers 2-1 in their last series. They enter this game with a 59-61 record overall and have a home record of 31-27. This is the 3rd game of a 3-game series with the Orioles on Wednesday with the 2nd game of this series still to be played on Tuesday. The Twins won the 1st game of this series on Monday. Their offense ranks 12th in the MLB with a .726 OPS. Bailey Ober is their starting pitcher on Tuesday while Zebby Matthews is making his start in this game on Wednesday. He is 5-8 with a 5.23 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 3 earned runs, 1 homer, and 2 walks with 4 strikeouts on 7 hits through 5 innings pitched against the Milwaukee Brewers.

The current betting odds have the Orioles listed as a slight underdog in this game according to Draftkings Sportsbook. The Orioles haven't looked great in their games this season with their 57-62 record overall which has them right near the bottom of the AL East. They haven't been a great road team either with their 25-32 road record this year. Meanwhile, the Twins haven't looked great in their games this season with their 59-61 record overall which has them right in the middle of the AL Central. They have looked better in their own ballpark though with their 31-27 home record this season. The Orioles are 4-6 in their last 10 games and they haven't looked great lately, but the Twins are also 4-6 in their last 10 games and haven't looked any better lately. The Orioles are going with Baz in this one and he hasn't looked bad this season. He is 4-11 with a 3.76 ERA and he hasn't been giving up many runs in his starts lately. The team has had a lot of trouble with him this year, losing 4 games in a row now with him starting, but he only gave up 2 earned runs in his last start and that has been a common theme for him. The Twins are going with Matthews in this one and he hasn't looked good this season. He is 5-8 with a 5.23 ERA and he has been giving up quite a few runs all year. The team has had some success with him lately, winning 2 games in a row now with him starting, but he did give up 3 earned runs in his last start and that has been a common theme for him. Both of these teams are fighting in the AL Wild Card race and both will be desperate to take this series, but the Orioles do have the edge with the better starter. The best way to place a bet here is on the Orioles to win this game. 

Orioles Twins Prediction:  Our MLB Pick for Wednesday, August 12, 2026 (1:40 pm ET start time) is Orioles 6 Twins 5.

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Baltimore Orioles: 57-62 (-7.5 units) on the moneyline in all games. 14-22 (-5.8 units) on the moneyline as a road underdog of +100 to +150. 5-10 (-8 units) on the moneyline vs. a starting pitcher who gives up 1 or more HR's/start. 27-17 OVER as a road underdog of +100 or higher.

Minnesota Twins: 14-12 (+5.3 units) on the moneyline against AL East opponents. 39-29 (+12.2 units) on the moneyline when playing against a team with a losing record. 44-35 (+12.8 units) on the moneyline vs. an AL team with an on base percentage .330 or worse. 37-20 OVER when the money line is +125 to -125.

Baltimore Orioles:  R. Mountcastle (1B) Sixty Day IL - Foot. S. Basallo (C) Ten Day IL - Shoulder. B. Alexander (3B) Ten Day IL - Hand. K. Akin (RP) Sixty Day IL - Elbow. R. Helsley (RP) Sixty Day IL - Elbow. C. Bassitt (SP) Sixty Day IL - Back. Z. Eflin (SP) Sixty Day IL - Elbow. J. Westburg (3B) Sixty Day IL - UCL. F. Bautista (RP) Sixty Day IL - Shoulder. C. Selby (SP) Sixty Day IL - Shoulder.

Minnesota Twins:  J. Ryan (SP) Fifteen Day IL - Glute. M. Paredes (SP) Sixty Day IL - Oblique. C. Sands (RP) Sixty Day IL - Elbow. B. Buxton (CF) Ten Day IL - Hip. A. Banda (RP) Sixty Day IL - Lat. M. Abel (SP) Sixty Day IL - Elbow. D. Festa (SP) Sixty Day IL - Shoulder. P. Lopez (SP) Sixty Day IL - Elbow.

“It looked like his glove side was higher than it usually was here, and then it looked like his release point was higher as well and threw a lot more four-seam [fastballs], which we knew coming in. That's what he did his last outing against Kansas City. But he still had the cutter going, the split was still there, and then he flashed a curveball when [he] needed to. So, that was a really good outing by Dean.” - Craig Albernaz after his team’s loss against the Twins in their game on Monday. 

“I think we were looking at the overall back of the baseball card. He had some tough starts earlier this year. He was injured. But I think we were looking at what he’s done over the last three or four years in Baltimore. And what he’d done there was be a really effective starter in the American League East, which is not an easy place to do it.” - Derek Shelton after his team’s win against the Orioles in their game on Monday. 

Gunnar Henderson (L) SS

Pete Alonso (R) 1B

Jackson Holliday (L) 2B

Tyler O'Neill (R) DH

Dylan Beavers (L) LF

Leody Taveras (S) RF

Coby Mayo (R) 3B

Colton Cowser (L) CF

Carlos Narváez (R) C

Austin Martin (R) LF

Ryan Jeffers (R) C

Royce Lewis (R) 2B

Josh Bell (S) DH

Luke Keaschall (R) RF

Brooks Lee (S) 3B

Kaelen Culpepper (R) SS

Victor Caratini (S) 1B

Ryan Kreidler (R) CF

Batting Average:  Blaze Alexander (.312)

Hits:  Pete Alonso (112)

Home Runs:  Pete Alonso (25)

RBI:  Pete Alonso (75)

Stolen Bases:  Leody Taveras (10)

Wins:  Brandon Young (8)

Saves:  Ryan Helsley (8)

ERA:  Jose Espada (0.00)

Batting Average:  Gabriel Gonzalez (.500)

Hits:  Josh Bell (107)

Home Runs:  Byron Buxton (25)

RBI:  Josh Bell (71)

Stolen Bases:  Luke Keaschall (14)

Wins:  Taj Bradley (9)

Saves:  Yoendrys Gómez (15)

ERA:  Jack Anderson (0.00)

Managers:

Baltimore Orioles: Craig Albernaz (1st season)

Minnesota Twins: Derek Shelton (1st season)