Baltimore Orioles vs Detroit Tigers Prediction, Preview and Odds - 07/29/2026

Game Time: 1:10 pm ET, Wednesday, July 29, 2026

Venue:  Comerica Park, Detroit, MI

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Orioles +139, Tigers -168; Over/Under:  8 runs

Bet365:  Moneyline odds:  Orioles +145, Tigers -175; Over/Under:  8 runs

BetMGM:  Moneyline odds:  Orioles +145, Tigers -175; Over/Under:  8 runs

Baltimore Orioles:  52-55 (4th place, AL East)

Detroit Tigers:  50-57 (4th place, AL Central)

Do not miss out on our expert handicapper analysis! Vegas Writer is on a HOT STREAK in MLB on an 18-10-1 MLB RUN for +$8,100 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Baltimore Orioles:  6-4 last 10

Detroit Tigers:  5-5 last 10

The Orioles are entering this series off a loss and lost their 3-game series against the Atlanta Braves 2-1 in their last series. They enter this game with a 52-55 record overall and have a road record of 23-28. This is the series finale of a 3-game series with the Tigers on Wednesday with the 2nd game still to be played on Tuesday. The Orioles won the series opener on Monday. Their offense ranks 17th in the MLB with a .720 OPS. Dean Kremer is their starting pitcher on Tuesday while Trevor Rogers is making his start in this game on Wednesday. He is 6-7 with a 4.17 ERA this season. His team won 5 of their last 6 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 2 ER, 0 HR, and 0 BB with 6 SO on 6 hits through 7 IP against the Atlanta Braves.

The Tigers are entering this series off a loss and split their 4-game series against the Kansas City Royals 2-2 in their last series. They enter this game with a 50-57 record overall and have a home record of 29-26. This is the 3rd game of a 3-game series with the Orioles on Wednesday with the 2nd game of this series still to be played on Tuesday. The Tigers lost the 1st game of this series on Monday. Their offense ranks 19th in the MLB with a .710 OPS. Troy Melton is their starting pitcher on Tuesday while Tarik Skubal is making his start in this game on Wednesday. He is 7-5 with a 2.70 ERA this season. His team won their last 2 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned runs, 0 homers, and 2 walks with 12 strikeouts on 4 hits through 7.1 innings pitched against the Kansas City Royals.

The current betting odds have the Tigers listed as a favorite in this game according to Draftkings Sportsbook. The Tigers haven't looked good in their games this season with their 50-57 record overall which has them right near the bottom of the AL Central. They have looked a lot better in their own ballpark though with their 29-26 home record this season. Meanwhile, the Orioles haven't looked good in their games this season with their 52-55 record overall which has them right near the bottom of the AL East. They have been a bad road team too with their 23-28 road record this year. The Orioles are 6-4 in their last 10 games and have been rolling lately while the Tigers are only 5-5 in their last 10 games and have lost some of their momentum, but this is a really important series for the Wild Card race and the Tigers do have the better pitching matchup here. The Tigers are going with Skubal in this one and he has looked great this season. He is 7-5 with a 2.70 ERA and he is their ace. He is coming off another great start giving up 1 earned run which has been a common theme for him throughout his career and the team has had more success with him lately too, winning 2 games in a row now with him starting. The Orioles are going with Rogers in this one and he has looked good this season. He is 6-7 with a 4.17 ERA and he has looked a lot better lately. He only gave up 2 earned runs in his last start and the team has won 5 of their last 6 games with him starting, but that hasn't been the case for a lot of the season and as bad as the Tigers have looked for a lot of the year, they have still looked a lot better at home. The Tigers have the edge at home in this pivotal series with the Orioles struggling on the road all year, so look for the Tigers to take advantage of this pitching matchup with their ace on the mound. The best way to place a bet here is on the Tigers to win this game. 

Orioles Tigers Prediction:  Our MLB Pick for Wednesday, July 29, 2026 (1:10 pm ET start time) is Tigers 2 Orioles 1.

Don't miss our champion handicappers free picks, best bets, and expert baseball picks today.  And if you enjoyed this Baltimore Orioles Detroit Tigers prediction, be sure to drop by every day for our daily MLB projections and previews.

Baltimore Orioles: 218-215 (-21.6 units) on the moneyline in all games. 58-65 (-10.3 units) on the moneyline against left-handed starters. 101-88 (-10.6 units) on the moneyline when playing against a team with a losing record. 35-21 UNDER as an underdog of +125 to +175.

Detroit Tigers: 49-36 (+16.3 units) on the moneyline against AL East opponents. 61-50 (+10.4 units) on the moneyline against left-handed starters. 78-64 (+12.7 units) on the moneyline vs. an AL starting pitcher whose WHIP is 1.300 or better. 34-19 UNDER as a favorite of -110 or higher.

Baltimore Orioles:  S. Basallo (C) Ten Day IL - Shoulder. A. Rutschman (C) Ten Day IL - Wrist. B. Alexander (3B) Ten Day IL - Hand. K. Akin (RP) Sixty Day IL - Elbow. R. Helsley (RP) Sixty Day IL - Elbow. C. Bassitt (SP) Sixty Day IL - Back. R. Mountcastle (1B) Sixty Day IL - Foot. Z. Eflin (SP) Sixty Day IL - Elbow. J. Westburg (3B) Sixty Day IL - UCL. F. Bautista (RP) Sixty Day IL - Shoulder. C. Selby (SP) Sixty Day IL - Shoulder.

Detroit Tigers:  K. Carpenter (RF) Ten Day - Heel. J. Flaherty (SP) Fifteen Day IL - Flexor. W. Vest (RP) Sixty Day IL - Elbow. B. Smith (RP) Sixty Day IL - Shoulder. W. Perez (RF) Sixty Day IL - Face. B. Hurter (RP) Sixty Day IL - Back. J. Baez (SS) Sixty Day IL - Ankle. J. Verlander (SP) Sixty Day IL - Hip. B. Horn (RP) Sixty Day IL - Elbow. P. Meadows (CF) Sixty Day IL - Head/Arm. T. Sweeney (SS) Sixty Day IL - Shoulder. R. Olson (SP) Sixty Day IL - Shoulder. J. Jobe (SP) Sixty Day IL - Elbow.

“It was just great at-bats. It was a great plan going in, and our guys were diligent and stubborn, and when he did make a mistake out over the plate, our guys put good swings on it. It was a really good offensive performance.” - Craig Albernaz after his team’s win against the Tigers in their game on Monday. 

“These are obviously tough. I just can’t live in a world where there’s this dramatic fall-off after you lose a game. We’ve got to play again tomorrow, and I’m trying to do my best to maintain that momentum moving forward. Of course we need to not lose three in a row, but I struggle sometimes to articulate what that means. Every time we lose, it’s this catastrophic loss. And we need to win the games. We needed to win the last two games. We needed to win tonight. We’re working. These guys are giving everything they have. But you’ve got to keep pushing. The game is going to continue to punch you in the face, and you’ve got to keep pushing." - A.J. Hinch after his team’s loss against the Orioles in their game on Monday. 

Dylan Beavers (L) RF

Pete Alonso (R) 1B

Gunnar Henderson (L) DH

Taylor Ward (R) LF

Leody Taveras (S) CF

Jackson Holliday (L) SS

Coby Mayo (R) 3B

Jeremiah Jackson (R) 2B

Chadwick Tromp (R) C

Kevin McGonigle (L) SS

Dillon Dingler (R) C

Colt Keith (L) 3B

Riley Greene (L) DH

Spencer Torkelson (R) 1B

Zach McKinstry (L) RF

Hao-Yu Lee (R) 2B

James Outman (L) CF

Matt Vierling (R) LF

Batting Average:  Christian Encarnacion-Strand (.370)

Hits:  Pete Alonso (101)

Home Runs:  Pete Alonso (22)

RBI:  Pete Alonso (67)

Stolen Bases:  Leody Taveras (10)

Wins:  Brandon Young (8)

Saves:  Ryan Helsley (8)

ERA:  Jose Espada (0.00)

Batting Average:  Eduardo Valencia (.417)

Hits:  Kevin McGonigle (110)

Home Runs:  Dillon Dingler (22)

RBI:  Dillon Dingler (68)

Stolen Bases:  Kevin McGonigle (11)

Wins:  Tarik Skubal (7)

Saves:  Kenley Jansen (12)

ERA:  Jacob Waguespack (1.47)

Managers:

Baltimore Orioles: Craig Albernaz (1st season)

Detroit Tigers: A.J. Hinch (6th season)