Baltimore Orioles vs Detroit Tigers Prediction, Preview and Odds - 07/28/2026

Game Time: 6:40 pm ET, Tuesday, July 28, 2026

Venue:  Comerica Park, Detroit, MI

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Orioles +119, Tigers -144; Over/Under:  9 runs

Bet365:  Moneyline odds:  Orioles +115, Tigers -135; Over/Under:  9 runs

BetMGM:  Moneyline odds:  Orioles +115, Tigers -140; Over/Under:  9 runs

Baltimore Orioles:  51-55 (4th place, AL East)

Detroit Tigers:  50-56 (4th place, AL Central)

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Baltimore Orioles:  6-4 last 10

Detroit Tigers:  6-4 last 10

The Orioles are entering this series off a loss and lost their 3-game series against the Atlanta Braves 2-1 in their last series. They enter this game with a 51-55 record overall and have a road record of 22-28. This is the 2nd game of a 3-game series with the Tigers on Tuesday with the series opener still to be played on Monday. Their offense ranks 17th in the MLB with a .717 OPS. Kyle Bradish is their starting pitcher on Monday while Dean Kremer is making his start in this game on Tuesday. He is 1-3 with a 5.06 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season appearance, he allowed 6 ER, 1 HR, and 1 BB with 5 SO on 8 hits through 6 IP against the Boston Red Sox.

The Tigers are entering this series off a loss and split their 4-game series against the Kansas City Royals 2-2 in their last series. They enter this game with a 50-56 record overall and have a home record of 29-25. This is the 2nd game of a 3-game series with the Orioles on Tuesday with the 1st game of this series still to be played on Monday. Their offense ranks 19th in the MLB with a .710 OPS. Keider Montero is their starting pitcher on Monday while Troy Melton is making his start in this game on Tuesday. He is 5-1 with a 1.95 ERA this season. His team won their last 4 straight games this season with him making an appearance. In his last MLB regular season start, he allowed 2 earned runs, 1 homer, and 4 walks with 5 strikeouts on 5 hits through 5 innings pitched against the Kansas City Royals.

The current betting odds have the Tigers listed as a favorite in this game according to Draftkings Sportsbook. The Tigers haven't looked good in their games this season with their 50-56 record overall which has them right near the bottom of the AL Central. They have looked a lot better in their own ballpark though with their 29-25 home record this season. Meanwhile, the Orioles haven't looked good in their games this season with their 51-55 record overall which has them right near the bottom of the AL East. They have been a bad road team too with their 22-28 road record this year. Both of these teams are 6-4 in their last 10 games respectively, but the Orioles were rolling their way back to .500 and have hit a snag now. They are coming off a series loss over the weekend and have been starting to cool off now while the Tigers are off a series split and have also been rolling their way back to .500 over the last few weeks. Neither offense has been anything special this season either, so the Tigers are going to be able to take advantage of this better pitching matchup. The Tigers are going with Melton in this one and he has looked great this season. He is 5-1 with a 1.95 ERA and he hasn't been giving up many runs lately. He is coming off another great start in which he gave up 2 earned runs which has been a common theme for him and the team has had a ton of success with him lately, winning 4 games in a row now with him starting. The Orioles are going with Kremer in this one and he hasn't looked great this season. He is 1-3 with a 5.06 ERA and he has been giving up quite a few runs. He just gave up 6 earned runs in his last start which has been a common theme for him and the team has lost 2 of their last 3 games with him starting too. Look for the Tigers to take advantage of this pitching matchup at home and catch the Orioles when they are starting to slump. The best way to place a bet here is on the Tigers to win this game. 

Orioles Tigers Prediction:  Our MLB Pick for Tuesday, July 28, 2026 (6:40 pm ET start time) is Tigers 5 Orioles 1.

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Baltimore Orioles: 217-215 (-22.7 units) on the moneyline in all games. 159-150 (-12.4 units) on the moneyline against right-handed starters. 100-88 (-11.7 units) on the moneyline when playing against a team with a losing record. 35-21 UNDER as an underdog of +125 to +175.

Detroit Tigers: 49-35 (+17.5 units) on the moneyline against AL East opponents. 78-64 (+12.7 units) on the moneyline vs. an AL starting pitcher whose WHIP is 1.300 or better. 30-17 (+10.9 units) on the moneyline vs. a starting pitcher who gives up 1 or more HR's/starts. 34-18 UNDER as a favorite of -110 or higher.

Baltimore Orioles:  S. Basallo (C) Ten Day IL - Shoulder. A. Rutschman (C) Ten Day IL - Wrist. B. Alexander (3B) Ten Day IL - Hand. K. Akin (RP) Sixty Day IL - Elbow. R. Helsley (RP) Sixty Day IL - Elbow. C. Bassitt (SP) Sixty Day IL - Back. R. Mountcastle (1B) Sixty Day IL - Foot. Z. Eflin (SP) Sixty Day IL - Elbow. J. Westburg (3B) Sixty Day IL - UCL. F. Bautista (RP) Sixty Day IL - Shoulder. C. Selby (SP) Sixty Day IL - Shoulder.

Detroit Tigers:  K. Carpenter (RF) Day To Day - Heel. J. Flaherty (SP) Fifteen Day IL - Flexor. W. Vest (RP) Sixty Day IL - Elbow. B. Smith (RP) Sixty Day IL - Shoulder. W. Perez (RF) Sixty Day IL - Face. B. Hurter (RP) Sixty Day IL - Back. J. Baez (SS) Sixty Day IL - Ankle. J. Verlander (SP) Sixty Day IL - Hip. B. Horn (RP) Sixty Day IL - Elbow. P. Meadows (CF) Sixty Day IL - Head/Arm. T. Sweeney (SS) Sixty Day IL - Shoulder. R. Olson (SP) Sixty Day IL - Shoulder. J. Jobe (SP) Sixty Day IL - Elbow.

“We’ve battled injuries all year, and guys have to step up. Either guys that are taking over that position, or other guys on the team.” - Craig Albernaz after his team’s loss against the Braves in their game on Sunday. 

“This left field’s really huge. If he’s safe, we’re loving life. If not, it’s a tough out. I think he knew Collins was pretty far back there. We play fearless, and you’re going to be barely out, barely safe. I know when it ends that way, it sucks, but it’s a style of play that we’ve been rewarded on a lot.” - A.J. Hinch after his team’s loss against the Royals in their game on Sunday. 

Dylan Beavers (L) LF

Pete Alonso (R) 1B

Gunnar Henderson (L) SS

Taylor Ward (R) DH

Christian Encarnacion-Strand (R) 3B

Colton Cowser (L) CF

Leody Taveras (S) RF

Jackson Holliday (L) 2B

Chadwick Tromp (R) C

Colt Keith (L) 3B

Kevin McGonigle (L) SS

Gleyber Torres (R) DH

Riley Greene (L) LF

Dillon Dingler (R) C

Kerry Carpenter (L) RF

Spencer Torkelson (R) 1B

James Outman (L) CF

Hao-Yu Lee (R) 2B

Batting Average:  Christian Encarnacion-Strand (.370)

Hits:  Pete Alonso (99)

Home Runs:  Pete Alonso (22)

RBI:  Pete Alonso (67)

Stolen Bases:  Leody Taveras (10)

Wins:  Brandon Young (8)

Saves:  Ryan Helsley (8)

ERA:  Jose Espada (0.00)

Batting Average:  Eduardo Valencia (.417)

Hits:  Kevin McGonigle (108)

Home Runs:  Dillon Dingler (22)

RBI:  Dillon Dingler (68)

Stolen Bases:  Kevin McGonigle (11)

Wins:  Tarik Skubal (7)

Saves:  Kenley Jansen (12)

ERA:  Jacob Waguespack (1.65)

Managers:

Baltimore Orioles: Craig Albernaz (1st season)

Detroit Tigers: A.J. Hinch (6th season)