Arizona Diamondbacks vs Pittsburgh Pirates Prediction, Preview and Odds - 07/29/2026

Game Time: 12:35 pm ET, Wednesday, July 29, 2026

Venue:  PNC Park, Pittsburgh, PA 

Where to Watch:  MLB TV

DraftKings:  Moneyline odds:  Diamondbacks +113, Pirates -136; Over/Under:  8.5 runs

Bet365:  Moneyline odds:  Diamondbacks +115, Pirates -135; Over/Under:  8.5 runs

BetMGM:  Moneyline odds:  Diamondbacks +115, Pirates -135; Over/Under:  8.5 runs

Arizona Diamondbacks:  55-52 (2nd place, NL West)

Pittsburgh Pirates:  55-52 (3rd place, NL Central)

Do not miss out on our expert handicapper analysis! Vegas Writer is on a HOT STREAK in MLB on an 18-10-1 MLB RUN for +$8,100 PROFIT! Make sure you check out his picks and many more from the expert handicappers featured in the Shop Picks section.

Arizona Diamondbacks:  6-4 last 10

Pittsburgh Pirates:  5-5 last 10

The Diamondbacks are entering this series off a loss and lost their 3-game series against the Washington Nationals 2-1 in their last series. They enter this game with a 55-52 record overall and have a road record of 24-30. This is the series finale of a 3-game series with the Pirates on Wednesday with the 2nd game still to be played on Tuesday. The Diamondbacks lost the series opener on Monday. Their offense ranks 20th in the MLB with a .706 OPS. Brandon Pfaadt is their starting pitcher on Tuesday while Eduardo Rodríguez is making his start in this game on Wednesday. He is 9-3 with a 2.64 ERA this season. His team won their last 3 straight games this season with him making an appearance. In his last MLB regular season appearance, he allowed 2 ER, 1 HR, and 3 BB with 4 SO on 7 hits through 6 IP against the Washington Nationals.

The Pirates are entering this series off a win and lost their 3-game series against the Chicago Cubs 2-1 in their last series. They enter this game with a 55-52 record overall and have a home record of 29-26. This is the 3rd game of a 3-game series with the Diamondbacks on Wednesday with the 2nd game of this series still to be played on Tuesday. The Pirates won the 1st game of this series on Monday. Their offense ranks 3rd in the MLB with a .758 OPS. Bubba Chandler is their starting pitcher on Tuesday while Jared Jones is making his start in this game on Wednesday. He is 2-1 with a 3.72 ERA this season. His team lost 2 of their last 3 games this season with him making an appearance. In his last MLB regular season start, he allowed 1 earned run, 1 homer, and 1 walk with 5 strikeouts on 2 hits through 6 innings pitched against the Chicago Cubs.

The current betting odds have the Diamondbacks listed as an underdog in this game according to Draftkings Sportsbook. The Diamondbacks have looked good in their games this season with their 55-52 record overall which has them right near the top of the NL West. They haven't been a great road team though with their 24-30 road record this year. Meanwhile, the Pirates have looked good in their games this season with their 55-52 record overall which has them right in the middle of the NL Central. They have looked better in their own ballpark too with their 29-26 home record this season. The Pirates took the 1st game of this series on Monday and they have one of the best offenses in MLB this season, but lately they haven't been putting up a ton of runs and they are only 5-5 in their last 10 games now. The Diamondbacks have been rolling lately, going 6-4 in their last 10 games, and they are going to have the better pitching matchup here too. The Diamondbacks are going with Rodriguez in this one and he has looked great this season. He is 9-3 with a 2.64 ERA and has easily been their best starter this year. He is coming off another great start giving up just 2 earned runs which has been a common theme for him and the team has been having a ton of success with him lately too, winning 3 games in a row now with him starting. The Pirates are going with Jones in this one and he has looked good this season. He is 2-1 with a 3.72 ERA and hasn't been giving up many runs lately, but the team has been having more trouble with him. He only gave up 1 earned run in his last start, but the team has lost 2 of their last 3 games with him starting and the bullpen has been a big issue for them all season. Between this Pirates bullpen and the more up and down starter, the Diamondbacks have the edge here and can take advantage of this pitching matchup. The best way to place a bet here is on the Diamondbacks to win this game. 

Diamondbacks Pirates Prediction:  Our MLB Pick for Wednesday, July 29, 2026 (12:35 pm ET start time) is Diamondbacks 3 Pirates 1.

Don't miss our champion handicappers free picks, best bets, and expert baseball picks today.  And if you enjoyed this Arizona Diamondbacks Pittsburgh Pirates prediction, be sure to drop by every day for our daily MLB projections and previews.

Arizona Diamondbacks: 105-110 (+7.8 units) on the moneyline in road games. 88-106 (+8.2 units) on the moneyline as an underdog of +100 or higher. 109-110 (+11.1 units) on the moneyline when playing against a team with a winning record. 98-60 OVER when the total is 8 to 8.5.

Pittsburgh Pirates: 36-43 (-6.3 units) on the moneyline against NL West opponents. 203-228 (-16.9 units) on the moneyline in all games. 86-68 (-8.9 units) on the moneyline as a favorite of -110 or higher. 35-21 OVER as a home favorite of -125 to -175.

Arizona Diamondbacks:  D. Jameson (RP) Fifteen Day IL - Hip. L. Gurriel Jr. (LF) Ten Day IL - Adductor. T. Troy (LF) Ten Day IL - Shoulder. Z. Gallen (SP) Fifteen Day IL - Elbow. J. Lawlar (LF) Ten Day IL - Hamstring. M. Soroka (SP) Fifteen Day IL - Lower-Body. R. Nelson (SP) Sixty Day IL - Elbow. B. Walston (SP) Sixty Day IL - Elbow. C. Mena (SP) Sixty Day IL - Shoulder. A. Puk (RP) Sixty Day IL - Elbow. C. Burnes (SP) Sixty Day IL - Elbow. J. Martinez (RP) Sixty Day IL - Elbow. A. Saalfrank (RP) Sixty Day IL - Shoulder.

Pittsburgh Pirates:  E. Valdez (RF) Day To Day - Hand. R. Flores Jr. (C) Seven Day IL - Head. O. Cruz (CF) Sixty Day IL - Hand. K. Griffin (SS) Sixty Day IL - Finger. E. Sisk (RP) Fifteen Day IL - Elbow. S. Horwitz (1B) Ten Day IL - Hamstring. C. Devenski (RP) Sixty Day IL - Illness.

"Ground-ball base hits down lines in this ballpark end up scoring two runs, and I felt like it was only the tying run [if Reynolds got a hit]. And I believed that we could pitch around him. [Loáisiga] has got nasty stuff with swing and miss. If we executed, I felt like we were going to strike out the batter. But overall, probably the gaps and in this ballpark with the winning run on first base was something that I was targeting and I was trying to avoid, but it didn't work out the way we wanted." - Torey Lovullo after his team’s loss against the Pirates in their game on Monday. 

“[Valdez] gets hurt, and I think it just speaks to the way the team has competed all year. It's just next man up. Let's keep on going and find a way. That was a playoff atmosphere there, and the guys know it, and they competed like it.” - Don Kelly after his team’s win against the Diamondbacks in their game on Monday. 

Corbin Carroll (L) RF

Geraldo Perdomo (S) SS

Gabriel Moreno (R) C

Ketel Marte (S) 2B

Max Kepler (L) LF

Tyler Locklear (R) 1B

Adrian Del Castillo (L) DH

Ildemaro Vargas (S) 3B

Ryan Waldschmidt (R) CF

Jake Mangum (S) CF

Brandon Lowe (L) 2B

Bryan Reynolds (S) LF

Esmerlyn Valdez (R) RF

Ryan O'Hearn (L) DH

Nick Gonzales (R) 3B

Jacob Gonzalez (L) SS

Tyler Callihan (L) 1B

Henry Davis (R) C

Batting Average:  Jordan Lawlar (.316)

Hits:  Ketel Marte (105)

Home Runs:  Ketel Marte (19)

RBI:  Ketel Marte (61)

Stolen Bases:  Geraldo Perdomo (17)

Wins:  Eduardo Rodriguez (9)

Saves:  Paul Sewald (24)

ERA:  Taylor Clarke (2.23)

Batting Average:  Nick Gonzales (.315)

Hits:  Nick Gonzales (120)

Home Runs:  Brandon Lowe (21)

RBI:  Ryan O'Hearn (68)

Stolen Bases:  Oneil Cruz (21)

Wins:  Braxton Ashcraft (10)

Saves:  Gregory Soto (13)

ERA:  Khristian Curtis (0.00)

Managers:

Arizona Diamondbacks: Torey Lovullo (10th season)

Pittsburgh Pirates: Don Kelly (2nd season)